STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)    
Predicted Functional Partners:
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 0.999
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
 
 0.997
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.983
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
  
 0.983
hpt
Hypoxanthine-guanine phosphoribosyltransferase; Similar to GB:K00558, GB:S62639, SP:P04687, SP:P05215, PID:340019, PID:340021, and PID:37492; identified by sequence similarity; putative.
  
 
 0.969
gmk-2
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.969
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
 
 
 0.962
pheT
phenylalanyl-tRNA synthetase, beta subunit; Similar to GB:J04809, SP:P00568, and PID:178322; identified by sequence similarity; putative; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.959
EF_3266
Ham1 family protein, putative; Similar to GB:L16499, GB:X67235, GB:Z21533, SP:Q03014, PID:292405, PID:32069, and PID:32548; identified by sequence similarity; putative.
 
 
 0.957
lysS
lysyl-tRNA synthetase; Similar to GB:Z21958, GB:M25668, GB:L12563, GB:U01828, SP:P11137, GB:U32995, GB:U34059, GB:U34061, GB:U34064, GB:U34065, GB:U34069, GB:U34060, GB:U34062, GB:U34063, GB:U34066, PID:1850617, PID:187381, and PID:409875; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.951
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.