STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldh-1L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (327 aa)    
Predicted Functional Partners:
EF_2158
Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Similar to GP:4972241, GB:L10243, and PID:152631; identified by sequence similarity; putative.
  
 0.995
EF_2559
Pyruvate flavodoxin/ferredoxin oxidoreductase family protein; Similar to GP:4972241, GB:L10243, and PID:152631; identified by sequence similarity; putative.
  
 
 0.988
pyk
Pyruvate kinase; Identified by match to PFAM protein family HMM PF02629; Belongs to the pyruvate kinase family.
  
 0.982
pflB
Formate acetyltransferase; Similar to SP:P09373, GB:X54936, GB:A18411, SP:P49763, PID:35522, and PID:512449; identified by sequence similarity; putative.
   
 
 0.955
pdhA
Pyruvate dehydrogenase complex E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
   
 
 0.952
pycA
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.941
pdhB
Pyruvate dehydrogenase complex, E1 component, beta subunit; Similar to GP:7107452, and SP:P21882; identified by sequence similarity; putative.
  
 0.940
EF_1206
Malate dehydrogenase, decarboxylating; Similar to GP:1006839, and GP:1006839; identified by sequence similarity; putative.
  
 0.929
EF_3316
Malic enzyme family protein; Similar to GP:6249490; identified by sequence similarity; putative.
  
 0.929
bkdB
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit; Similar to GP:5901697, and GP:5901697; identified by sequence similarity; putative.
  
 0.924
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.