STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gelECoccolysin; Metalloprotease capable of the hydrolysis of insoluble hydrophobic substrates. Hydrolyzes azocoll and gelatin and, at a lower rate, soluble and insoluble collagens. Does not cleave short synthetic peptides. Preferentially hydrolyzes the 24-Phe-|-Phe-25 bond in the insulin B-chain, followed by the 5-His-|-Leu-6 bond. Inactivates endothelin-1, primarily by cleavage of the 5-Ser-|-Leu-6 and 16-His-|- Leu-17 bonds. Hydrolyzes the alpha chain of C3 to generate a C3b-like protein. Inhibits complement-mediated hemolysis and opsinization of bacteria. Hydrolyzes the insect antimicro [...] (510 aa)    
Predicted Functional Partners:
EF_1817
Serine proteinase, V8 family; Similar to GB:Z11559, GB:M58510, SP:P21399, PID:33963, PID:896473, GB:Z11559, GB:M58510, SP:P21399, PID:33963, and PID:896473; identified by sequence similarity; putative; Belongs to the peptidase S1B family.
  
  
 0.953
agrBfs
agrBfs protein; May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor required for the regulation of the virulence genes for gelatinase (gelE) and a serine protease (sprE). Belongs to the AgrB family.
     
 0.897
fsrA
Response regulator; Similar to GP:2564260, GB:X70340, GB:K03222, SP:P01135, PID:183080, PID:339538, PID:339546, and PID:37090; identified by sequence similarity; putative.
     
 0.875
asa1
Aggregation substance; Aggregation substance allows donor and recipient strains to form tight aggregates which allow the non-motile bacteria to maintain physical contact over a period of time sufficient to permit conjugative transfer of the sex pheromone plasmid from donor to recipient strains.
      
 0.830
eep
Membrane-associated zinc metalloprotease, putative; Involved in production of the peptide pheromone cAD1.
      
 0.830
cylM
cylM protein; Similar to GB:U05682, GB:X72886, SP:Q06418, PID:2329845, PID:312336, PID:463470, PID:622985, PID:624881, GB:U05682, GB:X72886, SP:Q06418, PID:2329845, PID:312336, PID:463470, PID:622985, and PID:624881; identified by sequence similarity; putative.
      
 0.824
vanB
D-alanine--D-lactate ligase; Required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding.
      
 0.824
tdc
Decarboxylase, putative; Catalyzes the decarboxylation of L-tyrosine to produce tyramine. Plays a role in acid resistance since tyramine production via tyrosine decarboxylation appears to provide a cytosolic pH maintenance mechanism that helps the bacterium cope with acid stress such as that encountered in gastrointestinal tract (GIT) environments. Therefore, may contribute to the colonization of the human GIT by E.faecalis.
      
 0.751
EF_1097
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.701
EF_2076
Endocarditis specific antigen; Similar to GB:Z11559, GB:M58510, SP:P21399, PID:33963, PID:896473, GB:Z11559, GB:M58510, SP:P21399, PID:33963, and PID:896473; identified by sequence similarity; putative; Belongs to the bacterial solute-binding protein 9 family.
      
 0.697
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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