STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
agrBfsagrBfs protein; May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor required for the regulation of the virulence genes for gelatinase (gelE) and a serine protease (sprE). Belongs to the AgrB family. (242 aa)    
Predicted Functional Partners:
EF_1820
Histidine kinase, putative; Similar to GP:6492220, and GP:6492220; identified by sequence similarity; putative.
 
 
 0.992
fsrA
Response regulator; Similar to GP:2564260, GB:X70340, GB:K03222, SP:P01135, PID:183080, PID:339538, PID:339546, and PID:37090; identified by sequence similarity; putative.
  
  
 0.954
gelE
Coccolysin; Metalloprotease capable of the hydrolysis of insoluble hydrophobic substrates. Hydrolyzes azocoll and gelatin and, at a lower rate, soluble and insoluble collagens. Does not cleave short synthetic peptides. Preferentially hydrolyzes the 24-Phe-|-Phe-25 bond in the insulin B-chain, followed by the 5-His-|-Leu-6 bond. Inactivates endothelin-1, primarily by cleavage of the 5-Ser-|-Leu-6 and 16-His-|- Leu-17 bonds. Hydrolyzes the alpha chain of C3 to generate a C3b-like protein. Inhibits complement-mediated hemolysis and opsinization of bacteria. Hydrolyzes the insect antimicro [...]
     
 0.897
EF_1817
Serine proteinase, V8 family; Similar to GB:Z11559, GB:M58510, SP:P21399, PID:33963, PID:896473, GB:Z11559, GB:M58510, SP:P21399, PID:33963, and PID:896473; identified by sequence similarity; putative; Belongs to the peptidase S1B family.
     
 0.881
cylM
cylM protein; Similar to GB:U05682, GB:X72886, SP:Q06418, PID:2329845, PID:312336, PID:463470, PID:622985, PID:624881, GB:U05682, GB:X72886, SP:Q06418, PID:2329845, PID:312336, PID:463470, PID:622985, and PID:624881; identified by sequence similarity; putative.
 
  
 0.840
asa1
Aggregation substance; Aggregation substance allows donor and recipient strains to form tight aggregates which allow the non-motile bacteria to maintain physical contact over a period of time sufficient to permit conjugative transfer of the sex pheromone plasmid from donor to recipient strains.
  
   
 0.558
EF_3013
Conserved domain protein; Similar to GP:6470204; identified by sequence similarity; putative.
  
     0.506
EF_1097
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.499
EF_0248
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.481
EF_1051
Sensor histidine kinase; Identified by match to PFAM protein family HMM PF03070.
  
  
 0.450
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.