STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vanRBDNA-binding response regulator VanRB; Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. (220 aa)    
Predicted Functional Partners:
vanSB
Sensor histidine kinase VanSB; Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates VanR by phosphorylation.
 0.999
vanB
D-alanine--D-lactate ligase; Required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding.
     
 0.858
vanX
D-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. Belongs to the peptidase M15D family.
     
 0.857
EF_1051
Sensor histidine kinase; Identified by match to PFAM protein family HMM PF03070.
 
 0.827
EF_0373
Sensor histidine kinase; Similar to GB:U09281, GB:U09280, GB:U09279, PID:1468955, PID:1468956, PID:532764, PID:532768, and PID:624871; identified by sequence similarity; putative.
 
 0.803
vanYB
D-alanyl-D-alanine carboxypeptidase; Carboxypeptidase that cleaves the C-terminal D-alanine residue from the peptidoglycan-derived pentapeptide L-Ala-gamma-D-Glu- L-Lys-D-Ala-D-Ala in vitro. Therefore, should contribute in vivo to the hydrolysis of the D-alanyl-D-alanine-containing peptidoglycan precursors. May increase the level of glycopeptide antibiotics resistance by decreasing the availability of D-Ala-D-Ala termini from the cell surface, which constitute the antibiotic target residues.
  
  
 0.801
EF_0927
Sensor histidine kinase; Similar to GP:4104596; identified by sequence similarity; putative.
 
 0.800
EF_1704
Sensory box histidine kinase; Similar to GP:10175778; identified by sequence similarity; putative.
 
 0.781
EF_1261
Sensor histidine kinase; Similar to GP:4104609; identified by sequence similarity; putative.
 
 0.772
EF_3290
Sensor histidine kinase; Similar to GP:4104606; identified by sequence similarity; putative.
 
 0.739
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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