STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mecANegative regulator of genetic competence MecA, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (220 aa)    
Predicted Functional Partners:
EF_2675
Competence protein, putative; Similar to GP:3211759, GB:X07804, and PID:45810; identified by sequence similarity; putative.
 
   
 0.870
spxA
Conserved hypothetical protein; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
  
  
 0.839
vanB
D-alanine--D-lactate ligase; Required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding.
     
 0.808
pepF
Oligoendopeptidase F,plasmid; Similar to GB:M15502, SP:P07954, PID:1545996, and PID:182794; identified by sequence similarity; putative.
       0.789
EF_2673
Conserved domain protein.
  
  
 0.779
EF_0680
Penicillin-binding protein 2A; Similar to GP:2982644; identified by sequence similarity; putative.
  
   
 0.759
EF_2732
CBS domain protein; Identified by match to PFAM protein family HMM PF00571.
  
     0.733
EF_0689
Membrane protein, putative; Identified by match to PFAM protein family HMM PF03219.
  
     0.705
EF_2760
Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.694
rpoE
DNA-directed RNA polymerase, delta subunit, putative; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
  
     0.687
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.