STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa)    
Predicted Functional Partners:
EF_2870
HD domain protein; Identified by match to TIGR protein family HMM TIGR00277.
 
  
 0.997
nadE
NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
 
 
 0.991
EF_2872
Conserved hypothetical protein TIGR00253; Similar to GP:10173941; identified by sequence similarity; putative.
  
  
 0.960
cinA
Competence/damage-inducible protein CinA; Similar to GP:1842440, SP:Q04730, and PID:142946; identified by sequence similarity; putative; Belongs to the CinA family.
 
 
 0.959
nadK
Inorganic polyphosphate/ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
 0.946
EF_2626
Nicotinate phosphoribosyltransferase, putative; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
 
 0.939
cobB
Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
   
 0.936
EF_2873
GTPase of unknown function; Similar to GB:U11814, GB:M80634, SP:P21802, SP:Q01742, PID:1129107, PID:182567, PID:186741, PID:29432, and PID:530802; identified by sequence similarity; putative.
  
    0.928
EF_0062
Identified by match to PFAM protein family HMM PF02901.
     
  0.900
EF_2874
Hydrolase, HAD subfamily IIIA; Similar to GP:10173938; identified by sequence similarity; putative.
  
    0.898
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.