Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppdKPyruvate phosphate dikinase; Similar to SP:P22983, GB:X78969, and PID:474915; identified by sequence similarity; putative; Belongs to the PEP-utilizing enzyme family. (881 aa)    
Predicted Functional Partners:
EF_2158
Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Similar to GP:4972241, GB:L10243, and PID:152631; identified by sequence similarity; putative.
    
 0.981
EF_2559
Pyruvate flavodoxin/ferredoxin oxidoreductase family protein; Similar to GP:4972241, GB:L10243, and PID:152631; identified by sequence similarity; putative.
    
 0.981
pyk
Pyruvate kinase; Identified by match to PFAM protein family HMM PF02629; Belongs to the pyruvate kinase family.
    
 0.958
EF_1206
Malate dehydrogenase, decarboxylating; Similar to GP:1006839, and GP:1006839; identified by sequence similarity; putative.
  
 
 0.957
EF_1026
Conserved hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
 
  
 0.954
pycA
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
    
 0.951
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.937
EF_3316
Malic enzyme family protein; Similar to GP:6249490; identified by sequence similarity; putative.
  
 
 0.932
pflB
Formate acetyltransferase; Similar to SP:P09373, GB:X54936, GB:A18411, SP:P49763, PID:35522, and PID:512449; identified by sequence similarity; putative.
    
 0.926
ldh-1
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 
 0.921
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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