Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
EF_1111Signal peptidase I; Similar to GB:L22647, SP:P34995, PID:410209, GB:M89470, GB:L25597, SP:Q02962, PID:438650, and PID:553607; identified by sequence similarity; putative; Belongs to the peptidase S26 family. (182 aa)    
Predicted Functional Partners:
rexA
Exonuclease RexA; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily.
  
    0.799
rexB
Exonuclease RexB; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.
       0.780
EF_1114
Conserved hypothetical protein; Similar to GP:10173121; identified by sequence similarity; putative.
       0.734
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
 
 
 0.658
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
 
   
 0.598
eep
Membrane-associated zinc metalloprotease, putative; Involved in production of the peptide pheromone cAD1.
 
  
 0.582
EF_0655
Nitroreductase family protein, putative; Identified by match to PFAM protein family HMM PF00881.
       0.581
pbpC
Penicillin-binding protein C; Similar to SP:P13551, GB:X52165, SP:P13551, and GB:X52165; identified by sequence similarity; putative.
 
  
 0.564
rnc
Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
 
  
 0.552
EF_1033
6-aminohexanoate-cyclic-dimer hydrolase, putative; Similar to SP:P13397, GB:U03161, SP:P42512, and PID:454353; identified by sequence similarity; putative; Belongs to the amidase family.
     
 0.542
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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