STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EF_1678Signal peptidase I; Identified by match to PFAM protein family HMM PF00461; Belongs to the peptidase S26 family. (184 aa)    
Predicted Functional Partners:
EF_1679
Carboxyl-terminal protease; Similar to SP:P07126, GB:X06084, GB:X07013, PID:43377, SP:P07126, GB:X06084, GB:X07013, and PID:43377; identified by sequence similarity; putative; Belongs to the peptidase S41A family.
 
   
 0.786
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
 
   
 0.586
eep
Membrane-associated zinc metalloprotease, putative; Involved in production of the peptide pheromone cAD1.
 
  
 0.556
pbpC
Penicillin-binding protein C; Similar to SP:P13551, GB:X52165, SP:P13551, and GB:X52165; identified by sequence similarity; putative.
 
  
 0.534
EF_1680
Conserved hypothetical protein; Similar to GP:16414472, SP:P37623, PID:466611, GB:U00096, and PID:1789886; identified by sequence similarity; putative; Belongs to the UPF0346 family.
       0.529
msrA
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
     
 0.522
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.516
EF_1683
Lipase/Acylhydrolase, putative; Similar to GP:1850894; identified by sequence similarity; putative.
  
  
 0.515
EF_1677
Lipoprotein, putative.
       0.504
EF_1682
Conserved hypothetical protein; Similar to GB:X59871, GB:X59869, GB:X59870, SP:P36402, PID:36788, PID:619882, and PID:619884; identified by sequence similarity; putative.
       0.501
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.