node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EF_2364 | apt | EF_2364 | EF_1687 | Xanthine permease; Similar to SP:P42086, GB:X07820, SP:P09238, and PID:36629; identified by sequence similarity; putative. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.451 |
EF_2364 | guaA | EF_2364 | EF_0167 | Xanthine permease; Similar to SP:P42086, GB:X07820, SP:P09238, and PID:36629; identified by sequence similarity; putative. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.424 |
EF_2364 | guaC | EF_2364 | EF_2429 | Xanthine permease; Similar to SP:P42086, GB:X07820, SP:P09238, and PID:36629; identified by sequence similarity; putative. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.560 |
EF_2364 | purK-2 | EF_2364 | EF_2362 | Xanthine permease; Similar to SP:P42086, GB:X07820, SP:P09238, and PID:36629; identified by sequence similarity; putative. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. | 0.571 |
EF_2364 | xpt | EF_2364 | EF_2365 | Xanthine permease; Similar to SP:P42086, GB:X07820, SP:P09238, and PID:36629; identified by sequence similarity; putative. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. | 0.980 |
apt | EF_2364 | EF_1687 | EF_2364 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine permease; Similar to SP:P42086, GB:X07820, SP:P09238, and PID:36629; identified by sequence similarity; putative. | 0.451 |
apt | deoD-1 | EF_1687 | EF_0186 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.929 |
apt | gmk-1 | EF_1687 | EF_2595 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Similar to GP:7161953; identified by sequence similarity; putative. | 0.947 |
apt | gmk-2 | EF_1687 | EF_3127 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.947 |
apt | guaA | EF_1687 | EF_0167 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.983 |
apt | guaB | EF_1687 | EF_3293 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.477 |
apt | guaC | EF_1687 | EF_2429 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.929 |
apt | hpt | EF_1687 | EF_0264 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Similar to GB:K00558, GB:S62639, SP:P04687, SP:P05215, PID:340019, PID:340021, and PID:37492; identified by sequence similarity; putative. | 0.936 |
apt | xpt | EF_1687 | EF_2365 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. | 0.929 |
deoD-1 | apt | EF_0186 | EF_1687 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.929 |
deoD-1 | guaA | EF_0186 | EF_0167 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.621 |
deoD-1 | hpt | EF_0186 | EF_0264 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Hypoxanthine-guanine phosphoribosyltransferase; Similar to GB:K00558, GB:S62639, SP:P04687, SP:P05215, PID:340019, PID:340021, and PID:37492; identified by sequence similarity; putative. | 0.938 |
deoD-1 | xpt | EF_0186 | EF_2365 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. | 0.929 |
gmk-1 | apt | EF_2595 | EF_1687 | Guanylate kinase; Similar to GP:7161953; identified by sequence similarity; putative. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.947 |
gmk-1 | gmk-2 | EF_2595 | EF_3127 | Guanylate kinase; Similar to GP:7161953; identified by sequence similarity; putative. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.927 |