Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
EF_2500GcvH family protein; Similar to SP:P23884; identified by sequence similarity; putative. (104 aa)    
Predicted Functional Partners:
lpdA
Pyruvate dehydrogenase complex E3 component, dihydrolipoamide dehydrogenase; Similar to GB:M27375, GB:M27379, PID:1049145, PID:2358062, PID:292752, PID:619777, PID:975606, GB:M90354, SP:Q13890, and PID:179572; identified by sequence similarity; putative.
 
 0.973
bkdD
Branched-chain alpha-keto acid dehydrogenase, E3 component, dihydrolipoamide dehydrogenase; Similar to GP:5901695, and GP:5901695; identified by sequence similarity; putative.
 
 0.970
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.967
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.960
EF_2501
Arsenate reductase, putative; Similar to GP:10176108, and GP:10176108; identified by sequence similarity; putative; Belongs to the ArsC family.
 
  
 0.949
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.919
lipL
Lipoate-protein ligase A family protein, putative; Catalyzes the amidotransfer (transamidation) of the lipoyl moiety from lipoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. Takes part in a pathway for scavenging of lipoic acid; Belongs to the octanoyltransferase LipL family.
 
 
 0.885
EF_2502
Cell division protein, FtsW/RodA/SpoVE family; Similar to GP:10175898; identified by sequence similarity; putative; Belongs to the SEDS family.
  
  
 0.857
gdhA
Glutamate dehydrogenase; Similar to GP:10174720; identified by sequence similarity; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.837
glnA
Glutamine synthetase, type I; Identified by match to PFAM protein family HMM PF03951.
   
 
 0.835
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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