STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gshABGlutamate--cysteine ligase, putative/amino acid ligase, putative; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. (756 aa)    
Predicted Functional Partners:
ilvE
Branched-chain amino acid aminotransferase; Identified by match to TIGR protein family HMM TIGR01121.
  
 
 0.917
glnA
Glutamine synthetase, type I; Identified by match to PFAM protein family HMM PF03951.
  
 
 0.912
metC
Cystathionine beta-lyase; Similar to GP:6513595; identified by sequence similarity; putative.
    
 0.888
EF_0289
Cysteine synthase B, putative; Similar to SP:P26945, GB:X57853, PID:580700, SP:P26945, GB:X57853, and PID:580700; identified by sequence similarity; putative.
    
 0.863
cysK
Cysteine synthase A; Similar to SP:P37887; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.863
gltA
Glutamate synthase (NADPH), homotetrameric; Similar to GB:L19221, and PID:410147; identified by sequence similarity; putative.
     
 0.833
gdhA
Glutamate dehydrogenase; Similar to GP:10174720; identified by sequence similarity; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.822
EF_3090
Identified by match to PFAM protein family HMM PF00857.
       0.813
purQ
Phosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
    
  0.809
EF_0029
Aminotransferase, class II; Identified by match to TIGR protein family HMM TIGR01265.
     
  0.800
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.