| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BT_0744 | BT_1335 | BT_0744 | BT_1335 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | Folylpolyglutamate synthase. | 0.435 |
| BT_0744 | BT_2149 | BT_0744 | BT_2149 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.977 |
| BT_0744 | BT_3128 | BT_0744 | BT_3128 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.432 |
| BT_0744 | BT_3216 | BT_0744 | BT_3216 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine. | 0.908 |
| BT_0744 | BT_3646 | BT_0744 | BT_3646 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | Dihydropteroate synthase. | 0.977 |
| BT_0744 | BT_3728 | BT_0744 | BT_3728 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | Riboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.436 |
| BT_0744 | folE | BT_0744 | BT_3931 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | GTP cyclohydrolase I. | 0.772 |
| BT_1335 | BT_0744 | BT_1335 | BT_0744 | Folylpolyglutamate synthase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.435 |
| BT_1335 | BT_2149 | BT_1335 | BT_2149 | Folylpolyglutamate synthase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.610 |
| BT_1335 | BT_3128 | BT_1335 | BT_3128 | Folylpolyglutamate synthase. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.529 |
| BT_1335 | BT_3216 | BT_1335 | BT_3216 | Folylpolyglutamate synthase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine. | 0.551 |
| BT_1335 | BT_3646 | BT_1335 | BT_3646 | Folylpolyglutamate synthase. | Dihydropteroate synthase. | 0.996 |
| BT_1335 | BT_3728 | BT_1335 | BT_3728 | Folylpolyglutamate synthase. | Riboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.451 |
| BT_1335 | folE | BT_1335 | BT_3931 | Folylpolyglutamate synthase. | GTP cyclohydrolase I. | 0.694 |
| BT_2148 | BT_2149 | BT_2148 | BT_2149 | Glycoside transferase family 4. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.518 |
| BT_2149 | BT_0744 | BT_2149 | BT_0744 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.977 |
| BT_2149 | BT_1335 | BT_2149 | BT_1335 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthase. | 0.610 |
| BT_2149 | BT_2148 | BT_2149 | BT_2148 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Glycoside transferase family 4. | 0.518 |
| BT_2149 | BT_3128 | BT_2149 | BT_3128 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.585 |
| BT_2149 | BT_3216 | BT_2149 | BT_3216 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine. | 0.988 |