Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BT_3348Putative unsaturated glucuronyl hydrolase. (400 aa)    
Predicted Functional Partners:
BT_3349
Putative sulfatase yidJ; Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine. GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract.
 
    0.768
BT_3350
Putative chondroitinase (chondroitin lyase); Broad-specificity glycosaminoglycan lyase.
 
  
 0.747
BT_3233
Galactose mutarotase-like protein.
 
    0.734
BT_4410
Conserved hypothetical protein.
 
  
 0.670
BT_3232
Gluconate 5-dehydrogenase.
 
  
 0.642
BT_2964
Chondroitinase AC precursor.
 
  
 0.627
kduI1
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; Belongs to the KduI family.
 
  
 0.614
chonabc
Chondroitinase (chondroitin lyase) precursor; Broad-specificity glycosaminoglycan lyase, which acts in an exolytic fashion degrading chondroitin sulfates and dermatan sulfate to yield only disaccharide products. Has a preference for chondroitin 4- sulfate over chondroitin 6-sulfate. Has extremely low activity against hyaluronic acid. Is not active against acharan sulfate, heparin or heparan sulfate.
 
  
 0.613
kduI2
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; Belongs to the KduI family.
 
  
 0.600
BT_3334
Two-component system sensor histidine kinase/response regulator, hybrid (one-component system).
  
  
 0.569
Your Current Organism:
Bacteroides thetaiotaomicron
NCBI taxonomy Id: 226186
Other names: B. thetaiotaomicron VPI-5482, Bacteroides thetaiotaomicron VPI-5482, Bacteroides thetaiotaomicron str. VPI-5482, Bacteroides thetaiotaomicron strain VPI-5482
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.