Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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BT_4656N-acetylglucosamine-6-sulfatase precursor; Exosulfatase involved in the degradation of the glycosaminoglycan (GAG) heparan sulfate (HS). Catalyzes the hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units. GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract. Belongs to the sulfatase family. (558 aa)    
Predicted Functional Partners:
BT_4657
Heparinase III protein.
  
    0.679
BT_4655
Conserved hypothetical protein.
  
    0.559
BT_4658
Glucuronyl hydrolase.
  
    0.547
BT_3333
Arylsulfatase A precursor (ASA); Exosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Catalyzes the hydrolysis of the 6-sulfate groups of the N-acetyl- D-galactosamine 6-sulfate units. GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract.
 
  
0.456
BT_4654
ROK family transcriptional repressor, with glucokinase domain.
  
    0.455
BT_3590
alpha-N-acetylglucosaminidase precursor.
   
 
 0.451
BT_4359
alpha-N-acetylglucosaminidase precursor.
   
 
 0.451
BT_0985
Putative sialic acid-specific acetylesterase II.
   
  
 0.439
chuR
Transcriptional regulator; Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Links the heparin and the chondroitin sulfate utilization pathways which contribute to the colonization of the intestinal tract. May catalyze the activation of chondro-6-sulfatase, i.e. the post- translational modification of a specific serine residue into 3- oxoalanine (also known as C(alpha)-formylglycine (FGly)), by a free radical chemical mechanism initiated via the reductive cleavage of S- adenosyl-L-methionine (SAM). Is also able to oxidize a cysteine residue in a synthetic substrat [...]
 
    0.437
BT_0457
Sialic acid-specific 9-O-acetylesterase.
   
  
 0.437
Your Current Organism:
Bacteroides thetaiotaomicron
NCBI taxonomy Id: 226186
Other names: B. thetaiotaomicron VPI-5482, Bacteroides thetaiotaomicron VPI-5482, Bacteroides thetaiotaomicron str. VPI-5482, Bacteroides thetaiotaomicron strain VPI-5482
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