node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BC_2300 | lrgA | BC_2300 | BC_5439 | Oxalate/formate antiporter. | Murein hydrolase exporter; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.683 |
BC_2300 | lrgB | BC_2300 | BC_5438 | Oxalate/formate antiporter. | Murein hydrolase export regulator; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | 0.733 |
BC_3670 | BC_5133 | BC_3670 | BC_5133 | Murein hydrolase export regulator. | Murein hydrolase exporter. | 0.893 |
BC_3670 | cidA1 | BC_3670 | BC_3669 | Murein hydrolase export regulator. | Murein hydrolase exporter; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate t [...] | 0.998 |
BC_3670 | lrgA | BC_3670 | BC_5439 | Murein hydrolase export regulator. | Murein hydrolase exporter; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.899 |
BC_3754 | BC_5133 | BC_3754 | BC_5133 | Murein hydrolase export regulator. | Murein hydrolase exporter. | 0.892 |
BC_3754 | cidA1 | BC_3754 | BC_3669 | Murein hydrolase export regulator. | Murein hydrolase exporter; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate t [...] | 0.898 |
BC_3754 | lrgA | BC_3754 | BC_5439 | Murein hydrolase export regulator. | Murein hydrolase exporter; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.899 |
BC_5132 | BC_5133 | BC_5132 | BC_5133 | Murein hydrolase export regulator. | Murein hydrolase exporter. | 0.998 |
BC_5132 | cidA1 | BC_5132 | BC_3669 | Murein hydrolase export regulator. | Murein hydrolase exporter; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate t [...] | 0.899 |
BC_5132 | lrgA | BC_5132 | BC_5439 | Murein hydrolase export regulator. | Murein hydrolase exporter; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.898 |
BC_5132 | lytS | BC_5132 | BC_5441 | Murein hydrolase export regulator. | Autolysin sensor kinase; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. | 0.510 |
BC_5133 | BC_3670 | BC_5133 | BC_3670 | Murein hydrolase exporter. | Murein hydrolase export regulator. | 0.893 |
BC_5133 | BC_3754 | BC_5133 | BC_3754 | Murein hydrolase exporter. | Murein hydrolase export regulator. | 0.892 |
BC_5133 | BC_5132 | BC_5133 | BC_5132 | Murein hydrolase exporter. | Murein hydrolase export regulator. | 0.998 |
BC_5133 | codY | BC_5133 | BC_3826 | Murein hydrolase exporter. | Transcription pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.692 |
BC_5133 | lrgA | BC_5133 | BC_5439 | Murein hydrolase exporter. | Murein hydrolase exporter; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.865 |
BC_5133 | lrgB | BC_5133 | BC_5438 | Murein hydrolase exporter. | Murein hydrolase export regulator; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | 0.957 |
BC_5133 | lytS | BC_5133 | BC_5441 | Murein hydrolase exporter. | Autolysin sensor kinase; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. | 0.588 |
cidA1 | BC_3670 | BC_3669 | BC_3670 | Murein hydrolase exporter; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate t [...] | Murein hydrolase export regulator. | 0.998 |