STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCL60814.1Regulator of protease activity HflC, stomatin/prohibitin superfamily. (370 aa)    
Predicted Functional Partners:
ftsH
Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.985
SCL60820.1
Membrane protein implicated in regulation of membrane protease activity.
 
  
 0.980
SCL45381.1
Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family.
   
    0.767
arc
Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.732
SCL68312.1
Flotillin.
     
 0.672
SCL45095.1
Rhomboid family protein.
   
 0.657
SCL60493.1
Membrane associated serine protease, rhomboid family.
   
 0.657
SCL67971.1
Membrane associated serine protease, rhomboid family.
   
 0.657
SCL60825.1
CubicO group peptidase, beta-lactamase class C family.
       0.606
SCL51821.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
  0.586
Your Current Organism:
Micromonospora eburnea
NCBI taxonomy Id: 227316
Other names: DSM 44814, JCM 12345, M. eburnea, Micromonospora eburnea Thawai et al. 2005, Micromonospora sp. LK2-10, Micromonospora sp. LK2-5, Micromonospora sp. LK210, NBRC 101912, PCU 238, PCU:238, strain LK2-10
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