STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
palApH-response regulator protein palA/RIM20; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB via vps32 to its substrate pacC (By similarity); Belongs to the palA/RIM20 family. (847 aa)    
Predicted Functional Partners:
snf7
Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB).
    
 0.994
vps27
Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
   
 0.894
ANIA_02521
Endosomal sorting complex protein TSG101, putative (AFU_orthologue AFUA_3G14380).
   
 0.891
palB
Calpain-like protease palB; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Probably is the signaling protease that mediates the first proteolytic cleavage within the signaling protease box of pacC, yielding the 53 kDa 'open' conformation intermediate protein, which is committed to further processing. Required for virulence in invasive pulmonary aspergillosis (IPA).
    
 0.859
ANIA_03061
Vacuolar sorting ATPase Vps4, putative (AFU_orthologue AFUA_3G09360); Belongs to the AAA ATPase family.
   
 0.819
pacC
pH-response transcription factor pacC/RIM101 closed form; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA).
    
 
 0.817
ANIA_01365
SNF7 family protein (AFU_orthologue AFUA_1G09220).
    
 0.813
ANIA_07037
Vacuolar protein sorting protein (Vps36), putative (AFU_orthologue AFUA_4G04100).
     
 0.767
ANIA_02986
Calcium binding modulator protein (Alg2), putative (AFU_orthologue AFUA_3G08540).
  
 
 
 0.762
ANIA_05512
Magnesium dependent phosphatase, putative (AFU_orthologue AFUA_6G13100).
    
 0.753
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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