node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANIA_04208 | apdD | C8V4C4 | Q5ATH0 | O-acyltransferase. | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | 0.481 |
ANIA_06159 | apdD | Q5AZX1 | Q5ATH0 | O-acyltransferase. | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | 0.481 |
apdB | apdD | Q5ATH2 | Q5ATH0 | Cytochrome P450 monooxygenase apdB; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketi [...] | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | 0.626 |
apdB | apdG | Q5ATH2 | Q5ATG5 | Cytochrome P450 monooxygenase apdB; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketi [...] | Acyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] | 0.400 |
apdC | apdD | Q5ATH1 | Q5ATH0 | Trans-enoyl reductase apdC; Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of aspyridones (Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha- methylation step during polyketide synt [...] | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | 0.605 |
apdC | apdG | Q5ATH1 | Q5ATG5 | Trans-enoyl reductase apdC; Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of aspyridones (Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha- methylation step during polyketide synt [...] | Acyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] | 0.693 |
apdD | ANIA_04208 | Q5ATH0 | C8V4C4 | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | O-acyltransferase. | 0.481 |
apdD | ANIA_06159 | Q5ATH0 | Q5AZX1 | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | O-acyltransferase. | 0.481 |
apdD | apdB | Q5ATH0 | Q5ATH2 | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | Cytochrome P450 monooxygenase apdB; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketi [...] | 0.626 |
apdD | apdC | Q5ATH0 | Q5ATH1 | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | Trans-enoyl reductase apdC; Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of aspyridones (Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha- methylation step during polyketide synt [...] | 0.605 |
apdD | apdG | Q5ATH0 | Q5ATG5 | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | Acyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] | 0.630 |
apdD | aptA | Q5ATH0 | Q5B0D0 | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | Non-reducing polyketide synthase aptA; Non-reducing polyketide synthase (NRPKS); part of the gene cluster that mediates the biosynthesis of asperthecin, an anthraquinone pigment. Catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules. Through its product template (PT) domain, catalyzes the cyclization of the polyketide backbone via C6-C11 aldolcondensation. Polyketide is subsequently hydrolyzed from the NRPKS by the action of the hydrolase aptB into endocrocin-9-anthrone. Endocrocin-9-anthrone is then oxidized into endocrocin by [...] | 0.603 |
apdG | apdB | Q5ATG5 | Q5ATH2 | Acyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] | Cytochrome P450 monooxygenase apdB; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketi [...] | 0.400 |
apdG | apdC | Q5ATG5 | Q5ATH1 | Acyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] | Trans-enoyl reductase apdC; Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of aspyridones (Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha- methylation step during polyketide synt [...] | 0.693 |
apdG | apdD | Q5ATG5 | Q5ATH0 | Acyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | 0.630 |
aptA | apdD | Q5B0D0 | Q5ATH0 | Non-reducing polyketide synthase aptA; Non-reducing polyketide synthase (NRPKS); part of the gene cluster that mediates the biosynthesis of asperthecin, an anthraquinone pigment. Catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules. Through its product template (PT) domain, catalyzes the cyclization of the polyketide backbone via C6-C11 aldolcondensation. Polyketide is subsequently hydrolyzed from the NRPKS by the action of the hydrolase aptB into endocrocin-9-anthrone. Endocrocin-9-anthrone is then oxidized into endocrocin by [...] | FAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] | 0.603 |