node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANIA_00253 | ANIA_02637 | Q5BGS7 | Q5B9Z3 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | 0.512 |
ANIA_00253 | ANIA_05406 | Q5BGS7 | Q5B224 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.967 |
ANIA_00253 | ku70 | Q5BGS7 | Q5AVC7 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] | 0.558 |
ANIA_00253 | ku80 | Q5BGS7 | Q5B4H8 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] | 0.455 |
ANIA_00253 | sumO | Q5BGS7 | Q5BE39 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Ubiquitin-like domain-containing protein. | 0.886 |
ANIA_02637 | ANIA_00253 | Q5B9Z3 | Q5BGS7 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.512 |
ANIA_02637 | ANIA_04324 | Q5B9Z3 | C8V968 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | Putative b-zip transcription factor (Eurofung). | 0.593 |
ANIA_02637 | ANIA_04872 | Q5B9Z3 | G5EB17 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | Ubiquitin-like domain-containing protein. | 0.593 |
ANIA_02637 | ANIA_05406 | Q5B9Z3 | Q5B224 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.577 |
ANIA_02637 | ANIA_07723 | Q5B9Z3 | Q5AVF7 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | Origin recognition complex subunit 2, putative (AFU_orthologue AFUA_5G08110). | 0.572 |
ANIA_02637 | ANIA_10501 | Q5B9Z3 | C8V5Q0 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | annotation not available | 0.745 |
ANIA_02637 | ANIA_10855 | Q5B9Z3 | C8V2N1 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.465 |
ANIA_02637 | ku70 | Q5B9Z3 | Q5AVC7 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] | 0.630 |
ANIA_02637 | ku80 | Q5B9Z3 | Q5B4H8 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] | 0.588 |
ANIA_02637 | sumO | Q5B9Z3 | Q5BE39 | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | Ubiquitin-like domain-containing protein. | 0.699 |
ANIA_04324 | ANIA_02637 | C8V968 | Q5B9Z3 | Putative b-zip transcription factor (Eurofung). | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | 0.593 |
ANIA_04324 | ANIA_10501 | C8V968 | C8V5Q0 | Putative b-zip transcription factor (Eurofung). | annotation not available | 0.987 |
ANIA_04324 | sumO | C8V968 | Q5BE39 | Putative b-zip transcription factor (Eurofung). | Ubiquitin-like domain-containing protein. | 0.739 |
ANIA_04872 | ANIA_02637 | G5EB17 | Q5B9Z3 | Ubiquitin-like domain-containing protein. | Endonuclease/exonuclease/phosphatase family protein (AFU_orthologue AFUA_2G13650). | 0.593 |
ANIA_04872 | ANIA_10501 | G5EB17 | C8V5Q0 | Ubiquitin-like domain-containing protein. | annotation not available | 0.990 |