node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HSM_0320 | HSM_0744 | HSM_0320 | HSM_0744 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | 0.541 |
HSM_0320 | HSM_1196 | HSM_0320 | HSM_1196 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.989 |
HSM_0320 | HSM_1359 | HSM_0320 | HSM_1359 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: hso:HS_0880 folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.574 |
HSM_0320 | HSM_1503 | HSM_0320 | HSM_1503 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: hso:HS_1025 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.990 |
HSM_0320 | HSM_1534 | HSM_0320 | HSM_1534 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.556 |
HSM_0320 | folE | HSM_0320 | HSM_1388 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | PFAM: GTP cyclohydrolase I; KEGG: hso:HS_0910 GTP cyclohydrolase I. | 0.886 |
HSM_0744 | HSM_0320 | HSM_0744 | HSM_0320 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.541 |
HSM_0744 | HSM_1196 | HSM_0744 | HSM_1196 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.550 |
HSM_0744 | HSM_1503 | HSM_0744 | HSM_1503 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: hso:HS_1025 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.563 |
HSM_0744 | HSM_1534 | HSM_0744 | HSM_1534 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.642 |
HSM_0744 | HSM_2013 | HSM_0744 | HSM_2013 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | KEGG: hso:HS_0128 hypothetical protein. | 0.411 |
HSM_0744 | folE | HSM_0744 | HSM_1388 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | PFAM: GTP cyclohydrolase I; KEGG: hso:HS_0910 GTP cyclohydrolase I. | 0.428 |
HSM_0744 | guaB | HSM_0744 | HSM_0745 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.845 |
HSM_1196 | HSM_0320 | HSM_1196 | HSM_0320 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.989 |
HSM_1196 | HSM_0744 | HSM_1196 | HSM_0744 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: hso:HS_0419 biotin operon repressor. | 0.550 |
HSM_1196 | HSM_1359 | HSM_1196 | HSM_1359 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: hso:HS_0880 folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.997 |
HSM_1196 | HSM_1503 | HSM_1196 | HSM_1503 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: hso:HS_1025 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.999 |
HSM_1196 | HSM_1534 | HSM_1196 | HSM_1534 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.542 |
HSM_1196 | HSM_2013 | HSM_1196 | HSM_2013 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | KEGG: hso:HS_0128 hypothetical protein. | 0.919 |
HSM_1196 | folE | HSM_1196 | HSM_1388 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | PFAM: GTP cyclohydrolase I; KEGG: hso:HS_0910 GTP cyclohydrolase I. | 0.941 |