node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HSM_0155 | erpA | HSM_0155 | HSM_1296 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.733 |
HSM_0155 | hscB | HSM_0155 | HSM_0157 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.985 |
HSM_0155 | iscS | HSM_0155 | HSM_0154 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.999 |
HSM_0155 | nfuA | HSM_0155 | HSM_0510 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | HesB/YadR/YfhF-family protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.975 |
HSM_0324 | erpA | HSM_0324 | HSM_1296 | PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: hso:HS_1294 conserved hypothetical protein; Belongs to the GcvT family. | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.545 |
HSM_0324 | nfuA | HSM_0324 | HSM_0510 | PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: hso:HS_1294 conserved hypothetical protein; Belongs to the GcvT family. | HesB/YadR/YfhF-family protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.603 |
HSM_1294 | HSM_1295 | HSM_1294 | HSM_1295 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | PFAM: uncharacterised conserved protein UCP006287; KEGG: hso:HS_0826 hypothetical protein; Belongs to the UPF0231 family. | 0.786 |
HSM_1294 | erpA | HSM_1294 | HSM_1296 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.784 |
HSM_1294 | map | HSM_1294 | HSM_1297 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.549 |
HSM_1295 | HSM_1294 | HSM_1295 | HSM_1294 | PFAM: uncharacterised conserved protein UCP006287; KEGG: hso:HS_0826 hypothetical protein; Belongs to the UPF0231 family. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.786 |
HSM_1295 | erpA | HSM_1295 | HSM_1296 | PFAM: uncharacterised conserved protein UCP006287; KEGG: hso:HS_0826 hypothetical protein; Belongs to the UPF0231 family. | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.796 |
HSM_1295 | map | HSM_1295 | HSM_1297 | PFAM: uncharacterised conserved protein UCP006287; KEGG: hso:HS_0826 hypothetical protein; Belongs to the UPF0231 family. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.568 |
erpA | HSM_0155 | HSM_1296 | HSM_0155 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.733 |
erpA | HSM_0324 | HSM_1296 | HSM_0324 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: hso:HS_1294 conserved hypothetical protein; Belongs to the GcvT family. | 0.545 |
erpA | HSM_1294 | HSM_1296 | HSM_1294 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.784 |
erpA | HSM_1295 | HSM_1296 | HSM_1295 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | PFAM: uncharacterised conserved protein UCP006287; KEGG: hso:HS_0826 hypothetical protein; Belongs to the UPF0231 family. | 0.796 |
erpA | hscB | HSM_1296 | HSM_0157 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.478 |
erpA | iscS | HSM_1296 | HSM_0154 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.555 |
erpA | map | HSM_1296 | HSM_1297 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.557 |
erpA | nfuA | HSM_1296 | HSM_0510 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | HesB/YadR/YfhF-family protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.644 |