STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ibpACysteine protease domain, YopT-type; Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific tyrosine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation inactivates Rho GTPases, thereby inhibiting actin assembly in infected cells. Probably also acts as a cysteine protease, which may play a central role after invasion of host cell and in virulence. Possible member (with IbpB) of a 2 partner secretion. Probably able to bind bovine epithelial cells (host cells). May participate in the formation of fibrils a [...] (4095 aa)    
Predicted Functional Partners:
ibpB
Polypeptide-transport-associated domain protein ShlB-type; Possible member (with IbpA) of a two partner secretion pathway (TPS) in which it would mediate the secretion of protein IbpA (high molecular weight immunoglobulin-binding protein).
 
   
 0.934
HSM_0267
PFAM: Hemolysin activator HlyB domain protein; Polypeptide-transport-associated domain protein ShlB-type; KEGG: msu:MS1169 FhaC protein.
  
   
 0.766
HSM_1641
KEGG: msu:MS1167 FhaB protein.
  
   
 0.703
HSM_1647
KEGG: msu:MS1163 FhaB protein.
  
   
 0.700
HSM_1638
KEGG: msu:MS1164 hypothetical protein.
  
   
 0.688
HSM_0272
KEGG: msu:MS1162 hypothetical protein.
  
   
 0.680
HSM_0270
KEGG: nme:NMB1768 hemagglutinin/hemolysin-related protein.
  
   
 0.675
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 
 0.646
HSM_0274
KEGG: mfa:Mfla_0483 adhesin HecA 20-residue repeat X2.
  
   
 0.630
hscA
Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
    
   0.567
Your Current Organism:
Histophilus somni
NCBI taxonomy Id: 228400
Other names: H. somni 2336, Haemophilus somnus 2336, Histophilus somni 2336, Histophilus somni str. 2336
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.