node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HNE_0525 | HNE_1302 | HNE_0525 | HNE_1302 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | 0.939 |
HNE_0525 | dnaJ | HNE_0525 | HNE_0761 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.937 |
HNE_0525 | groES | HNE_0525 | HNE_1961 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.874 |
HNE_0525 | groL | HNE_0525 | HNE_1962 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.915 |
HNE_0525 | grpE | HNE_0525 | HNE_3318 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.980 |
HNE_0525 | hrcA | HNE_0525 | HNE_3317 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.871 |
HNE_0525 | hslU | HNE_0525 | HNE_2034 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.570 |
HNE_0525 | hslV | HNE_0525 | HNE_2033 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | ATP-dependent protease HslVU; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.476 |
HNE_0525 | lon | HNE_0525 | HNE_0977 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.655 |
HNE_1302 | HNE_0525 | HNE_1302 | HNE_0525 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | 0.939 |
HNE_1302 | dnaK | HNE_1302 | HNE_3321 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.990 |
HNE_1302 | groES | HNE_1302 | HNE_1961 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.717 |
HNE_1302 | groL | HNE_1302 | HNE_1962 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.866 |
HNE_1302 | grpE | HNE_1302 | HNE_3318 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.940 |
HNE_1302 | hrcA | HNE_1302 | HNE_3317 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.711 |
HNE_1302 | hslU | HNE_1302 | HNE_2034 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.637 |
HNE_1302 | hslV | HNE_1302 | HNE_2033 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | ATP-dependent protease HslVU; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.486 |
HNE_1302 | lon | HNE_1302 | HNE_0977 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.556 |
dnaJ | HNE_0525 | HNE_0761 | HNE_0525 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | 0.937 |
dnaJ | dnaK | HNE_0761 | HNE_3321 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |