node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HNE_0085 | HNE_3198 | HNE_0085 | HNE_3198 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Conserved hypothetical protein; Identified by similarity to GB:BAC50788.1. | 0.508 |
HNE_0085 | clpA | HNE_0085 | HNE_1030 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | ATP-dependent Clp protease, ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. | 0.664 |
HNE_0085 | clpB | HNE_0085 | HNE_0631 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.664 |
HNE_0085 | dnaK | HNE_0085 | HNE_3321 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.946 |
HNE_0085 | groES | HNE_0085 | HNE_1961 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.587 |
HNE_0085 | groL | HNE_0085 | HNE_1962 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.774 |
HNE_0085 | grpE | HNE_0085 | HNE_3318 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.863 |
HNE_0085 | hrcA | HNE_0085 | HNE_3317 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.712 |
HNE_1302 | clpA | HNE_1302 | HNE_1030 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | ATP-dependent Clp protease, ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. | 0.697 |
HNE_1302 | clpB | HNE_1302 | HNE_0631 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.697 |
HNE_1302 | dnaK | HNE_1302 | HNE_3321 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.990 |
HNE_1302 | groES | HNE_1302 | HNE_1961 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.717 |
HNE_1302 | groL | HNE_1302 | HNE_1962 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.866 |
HNE_1302 | grpE | HNE_1302 | HNE_3318 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.940 |
HNE_1302 | hrcA | HNE_1302 | HNE_3317 | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.711 |
HNE_3198 | HNE_0085 | HNE_3198 | HNE_0085 | Conserved hypothetical protein; Identified by similarity to GB:BAC50788.1. | DnaJ domain protein; Identified by match to protein family HMM PF00226. | 0.508 |
HNE_3198 | dnaK | HNE_3198 | HNE_3321 | Conserved hypothetical protein; Identified by similarity to GB:BAC50788.1. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.917 |
clpA | HNE_0085 | HNE_1030 | HNE_0085 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. | DnaJ domain protein; Identified by match to protein family HMM PF00226. | 0.664 |
clpA | HNE_1302 | HNE_1030 | HNE_1302 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. | Putative dnaJ protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF01556. | 0.697 |
clpA | dnaJ | HNE_1030 | HNE_0761 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.827 |