STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folE2DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. (268 aa)    
Predicted Functional Partners:
NE1517
6-pyruvoyl tetrahydropterin synthase.
    
 0.924
ribAB
ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
     
 0.905
ntpA
NUDIX hydrolase.
     
  0.900
NE0070
7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase.
    
 0.873
pykA1
Pyruvate kinase family; Belongs to the pyruvate kinase family.
    
  0.809
spoT
spoT; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.802
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
  0.800
NE1299
Guanylate cyclase.
     
  0.800
NE1496
Conserved hypothetical protein; Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside- linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi). The enzyme has a strong preference for linear PPPi compared with cyclic PPPi (cyclic trimetaphosphate) and to the linear P4. The longer chains polyphosphate are not hydrolyzed. It has only a slight thiamine triphosphatase (ThTPase) activity. Nucleoside triphosphatase activity is negligible in the presence of magnesium, but a small activity is observed in t [...]
     
  0.800
NE1847
Guanylate cyclase.
     
  0.800
Your Current Organism:
Nitrosomonas europaea
NCBI taxonomy Id: 228410
Other names: N. europaea ATCC 19718, Nitrosomonas europaea ATCC 19718, Nitrosomonas europaea str. ATCC 19718
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