node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NE1430 | anmK | NE1430 | NE1429 | Peptidase family M23/M37. | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.820 |
NE1430 | tyrS | NE1430 | NE1431 | Peptidase family M23/M37. | t-RNA synthetase, class Ib; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. | 0.703 |
ampD | ampG | NE2182 | NE2191 | N-acetylmuramoyl-L-alanine amidase (family 2). | Putative transport transmembrane protein. | 0.865 |
ampD | anmK | NE2182 | NE1429 | N-acetylmuramoyl-L-alanine amidase (family 2). | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.866 |
ampD | glmU | NE2182 | NE0208 | N-acetylmuramoyl-L-alanine amidase (family 2). | glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.459 |
ampD | mrsA | NE2182 | NE0530 | N-acetylmuramoyl-L-alanine amidase (family 2). | Phosphoglucomutase and phosphomannomutase family; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.473 |
ampD | murA | NE2182 | NE1852 | N-acetylmuramoyl-L-alanine amidase (family 2). | EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.491 |
ampD | murB | NE2182 | NE0993 | N-acetylmuramoyl-L-alanine amidase (family 2). | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.493 |
ampD | nagZ | NE2182 | NE2320 | N-acetylmuramoyl-L-alanine amidase (family 2). | Glycoside hydrolase family 3, N terminal; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.856 |
ampG | ampD | NE2191 | NE2182 | Putative transport transmembrane protein. | N-acetylmuramoyl-L-alanine amidase (family 2). | 0.865 |
ampG | anmK | NE2191 | NE1429 | Putative transport transmembrane protein. | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.853 |
ampG | glmU | NE2191 | NE0208 | Putative transport transmembrane protein. | glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.461 |
ampG | mrsA | NE2191 | NE0530 | Putative transport transmembrane protein. | Phosphoglucomutase and phosphomannomutase family; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.431 |
ampG | murA | NE2191 | NE1852 | Putative transport transmembrane protein. | EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.472 |
ampG | murB | NE2191 | NE0993 | Putative transport transmembrane protein. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.451 |
ampG | nagZ | NE2191 | NE2320 | Putative transport transmembrane protein. | Glycoside hydrolase family 3, N terminal; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.885 |
anmK | NE1430 | NE1429 | NE1430 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Peptidase family M23/M37. | 0.820 |
anmK | ampD | NE1429 | NE2182 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetylmuramoyl-L-alanine amidase (family 2). | 0.866 |
anmK | ampG | NE1429 | NE2191 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative transport transmembrane protein. | 0.853 |
anmK | glmU | NE1429 | NE0208 | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.596 |