node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NE1655 | bioA | NE1655 | NE0026 | Aminotransferases class-I. | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.961 |
NE1655 | bioB | NE1655 | NE2300 | Aminotransferases class-I. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.648 |
NE1655 | bioD | NE1655 | NE2296 | Aminotransferases class-I. | Cobyrinic acid a,c-diamide synthase:Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.796 |
NE1655 | bioF | NE1655 | NE2299 | Aminotransferases class-I. | Aminotransferases class-I; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.921 |
NE1655 | bioH | NE1655 | NE2298 | Aminotransferases class-I. | Possible BioH, catalyzes some early step in biotin biosynthesis; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.913 |
NE1655 | birA-2 | NE1655 | NE2460 | Aminotransferases class-I. | birA_ligase: biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.553 |
NE1655 | rkpA | NE1655 | NE1389 | Aminotransferases class-I. | Similar to (AF285636) putative type I polyketide synthase WcbR [Burkholderia mallei], evalue=0.00e+00, 41% identity. | 0.793 |
NE1655 | rkpG | NE1655 | NE1388 | Aminotransferases class-I. | Aminotransferases class-I. | 0.918 |
NE2205 | bioH | NE2205 | NE2298 | Possible transcriptional regulator; NE2204 and an unannotated ORF overlapping the 3' end are 2 parts of a dead gene due to a frameshift. | Possible BioH, catalyzes some early step in biotin biosynthesis; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.904 |
NE2205 | rkpA | NE2205 | NE1389 | Possible transcriptional regulator; NE2204 and an unannotated ORF overlapping the 3' end are 2 parts of a dead gene due to a frameshift. | Similar to (AF285636) putative type I polyketide synthase WcbR [Burkholderia mallei], evalue=0.00e+00, 41% identity. | 0.892 |
bioA | NE1655 | NE0026 | NE1655 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferases class-I. | 0.961 |
bioA | bioB | NE0026 | NE2300 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.985 |
bioA | bioD | NE0026 | NE2296 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Cobyrinic acid a,c-diamide synthase:Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioA | bioF | NE0026 | NE2299 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferases class-I; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.991 |
bioA | bioH | NE0026 | NE2298 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Possible BioH, catalyzes some early step in biotin biosynthesis; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.752 |
bioA | birA-2 | NE0026 | NE2460 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | birA_ligase: biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.902 |
bioA | rkpA | NE0026 | NE1389 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Similar to (AF285636) putative type I polyketide synthase WcbR [Burkholderia mallei], evalue=0.00e+00, 41% identity. | 0.615 |
bioA | rkpG | NE0026 | NE1388 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferases class-I. | 0.962 |
bioB | NE1655 | NE2300 | NE1655 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Aminotransferases class-I. | 0.648 |
bioB | bioA | NE2300 | NE0026 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.985 |