node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NE1655 | NE2420 | NE1655 | NE2420 | Aminotransferases class-I. | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | 0.532 |
NE1655 | bioA | NE1655 | NE0026 | Aminotransferases class-I. | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.961 |
NE1655 | bioB | NE1655 | NE2300 | Aminotransferases class-I. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.648 |
NE1655 | bioD | NE1655 | NE2296 | Aminotransferases class-I. | Cobyrinic acid a,c-diamide synthase:Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.796 |
NE1655 | bioF | NE1655 | NE2299 | Aminotransferases class-I. | Aminotransferases class-I; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.921 |
NE1655 | bioH | NE1655 | NE2298 | Aminotransferases class-I. | Possible BioH, catalyzes some early step in biotin biosynthesis; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.913 |
NE1655 | birA-2 | NE1655 | NE2460 | Aminotransferases class-I. | birA_ligase: biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.553 |
NE2301 | bioB | NE2301 | NE2300 | Conserved hypothetical protein; COGs COG1040. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.644 |
NE2301 | bioC | NE2301 | NE2297 | Conserved hypothetical protein; COGs COG1040. | SAM (and some other nucleotide) binding motif; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.666 |
NE2301 | bioD | NE2301 | NE2296 | Conserved hypothetical protein; COGs COG1040. | Cobyrinic acid a,c-diamide synthase:Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.610 |
NE2301 | bioF | NE2301 | NE2299 | Conserved hypothetical protein; COGs COG1040. | Aminotransferases class-I; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.613 |
NE2301 | bioH | NE2301 | NE2298 | Conserved hypothetical protein; COGs COG1040. | Possible BioH, catalyzes some early step in biotin biosynthesis; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.611 |
NE2301 | trmL | NE2301 | NE2302 | Conserved hypothetical protein; COGs COG1040. | rRNA_methyl_2: RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.834 |
NE2420 | NE1655 | NE2420 | NE1655 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | Aminotransferases class-I. | 0.532 |
NE2420 | bioA | NE2420 | NE0026 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.521 |
NE2420 | bioB | NE2420 | NE2300 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.596 |
NE2420 | bioD | NE2420 | NE2296 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | Cobyrinic acid a,c-diamide synthase:Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.553 |
NE2420 | bioF | NE2420 | NE2299 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | Aminotransferases class-I; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.532 |
NE2420 | birA-2 | NE2420 | NE2460 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. | birA_ligase: biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.968 |
bioA | NE1655 | NE0026 | NE1655 | Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferases class-I. | 0.961 |