node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHC50775.1 | AHC51289.1 | SUSAZ_01380 | SUSAZ_04375 | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.582 |
AHC50775.1 | AHC52365.1 | SUSAZ_01380 | SUSAZ_11080 | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.512 |
AHC50775.1 | thi4 | SUSAZ_01380 | SUSAZ_03885 | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribulose-1,5-biphosphate synthetase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.759 |
AHC50775.1 | thiC | SUSAZ_01380 | SUSAZ_00695 | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.951 |
AHC51196.1 | AHC51197.1 | SUSAZ_03860 | SUSAZ_03865 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.883 |
AHC51196.1 | AHC51199.1 | SUSAZ_03860 | SUSAZ_03875 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.874 |
AHC51196.1 | kae1 | SUSAZ_03860 | SUSAZ_03870 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family. | 0.898 |
AHC51196.1 | rps24e | SUSAZ_03860 | SUSAZ_03880 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 30S ribosomal protein S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.880 |
AHC51196.1 | thi4 | SUSAZ_03860 | SUSAZ_03885 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribulose-1,5-biphosphate synthetase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.729 |
AHC51196.1 | ubiX | SUSAZ_03860 | SUSAZ_03890 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.487 |
AHC51197.1 | AHC51196.1 | SUSAZ_03865 | SUSAZ_03860 | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.883 |
AHC51197.1 | AHC51199.1 | SUSAZ_03865 | SUSAZ_03875 | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | 30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.874 |
AHC51197.1 | kae1 | SUSAZ_03865 | SUSAZ_03870 | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | Protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family. | 0.992 |
AHC51197.1 | rps24e | SUSAZ_03865 | SUSAZ_03880 | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | 30S ribosomal protein S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.936 |
AHC51197.1 | thi4 | SUSAZ_03865 | SUSAZ_03885 | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribulose-1,5-biphosphate synthetase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.729 |
AHC51197.1 | ubiX | SUSAZ_03865 | SUSAZ_03890 | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.487 |
AHC51199.1 | AHC51196.1 | SUSAZ_03875 | SUSAZ_03860 | 30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.874 |
AHC51199.1 | AHC51197.1 | SUSAZ_03875 | SUSAZ_03865 | 30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine/threonine protein kinase; In Archaea, some Bud32-like proteins are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex; kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32); in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.874 |
AHC51199.1 | kae1 | SUSAZ_03875 | SUSAZ_03870 | 30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. | Protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family. | 0.874 |
AHC51199.1 | rps24e | SUSAZ_03875 | SUSAZ_03880 | 30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. | 30S ribosomal protein S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.990 |