STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
priSDNA primase; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play [...] (322 aa)    
Predicted Functional Partners:
priL
DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
 
 0.999
pcn-3
DNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.984
AHC50596.1
DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.969
AHC51755.1
Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein has been shown to be aphidicolin resistant and stable up to 80#C; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.967
AHC51553.1
Translation initiation factor IF-2 subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.960
AHC51552.1
Ribosome biogenesis protein Nop10; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.958
AHC51241.1
Minichromosome maintenance protein MCM; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MCM family.
 
 0.956
AHC52175.1
DNA polymerase II; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.955
rfc
ATPase AAA; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily.
  
 0.935
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
  
 0.935
Your Current Organism:
Sulfolobus acidocaldarius SUSAZ
NCBI taxonomy Id: 1435377
Other names: S. acidocaldarius SUSAZ
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.