STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCNEQ420; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1243 aa)    
Predicted Functional Partners:
polB
NEQ240; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
 
 
 
 0.971
pcn
NEQ537; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
 
 
 0.930
NEQ057
NEQ057; Involved in regulation of DNA replication.
     
 0.611
NEQ417
NEQ417; Glycyl-tRNA synthetase [Pyrococcus abyssi]; COG0423: Glycyl-tRNA synthetase, class II; IPR002106: Aminoacyl-transfer RNA synthetases class-II; IPR002314: tRNA synthetases, class-II (G, H, P and S); IPR002315: Homodimeric glycyl-tRNA synthetase.
       0.559
NEQ334
NEQ334; Nucleotide binding protein [Pyrococcus furiosus]; COG1491: Predicted RNA-binding protein; IPR001472: Bipartite nuclear localization signal.
  
     0.557
NEQ418
NEQ418; Hypothetical protein; IPR001472: Bipartite nuclear localization signal.
       0.543
thrS
NEQ177; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family.
      
 0.472
NEQ348
NEQ348; Putative histone A2 [Methanococcus jannaschii]; COG2036: Histones H3 and H4; IPR000947: Histone-like transcription factor (CBF/NF-Y) and archaeal histone, subunit A; IPR000166: Histone-fold/TFIID-TAF/NF-Y domain.
  
     0.453
NEQ414
NEQ414; Conserved hypothetical protein [Pyrococcus furiosus]; COG1750: Archaeal serine proteases; IPR001984: ATP-dependent serine proteases, Lon family; IPR000531: TonB-dependent receptor protein.
       0.449
NEQ416
NEQ416; Hypothetical protein; IPR000531: TonB-dependent receptor protein.
       0.423
Your Current Organism:
Nanoarchaeum equitans
NCBI taxonomy Id: 228908
Other names: Microarchaeum sp. Kin4-M, N. equitans Kin4-M, Nanoarchaeum equitans Kin4-M, Nanoarchaeum equitans str. Kin4-M
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.