KPL72147.1 protein (Leptolinea tardivitalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KPL72147.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (789 aa)

Predicted Functional Partners:

KPL71108.1

0.999

KPL73008.1

0.995

KPL70455.1

0.993

KPL72598.1

0.991

KPL71200.1

0.987

KPL71117.1

0.987

KPL70512.1

0.987

KPL70514.1

0.987

KPL73479.1

0.981

KPL71113.1

0.981

Your Current Organism:

Leptolinea tardivitalis

NCBI taxonomy Id: 229920
Other names: DSM 16556, JCM 12579, L. tardivitalis, Leptolinea tardivitalis Yamada et al. 2006, anaerobic filamentous bacterium YMTK-2, strain YMTK-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KPL70455.1	KPL70512.1	ADM99_15060	ADM99_15415	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
KPL70455.1	KPL70514.1	ADM99_15060	ADM99_15425	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
KPL70455.1	KPL71108.1	ADM99_15060	ADM99_12625	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
KPL70455.1	KPL71113.1	ADM99_15060	ADM99_12650	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
KPL70455.1	KPL71117.1	ADM99_15060	ADM99_12685	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
KPL70455.1	KPL71200.1	ADM99_15060	ADM99_12675	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
KPL70455.1	KPL72147.1	ADM99_15060	ADM99_08365	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
KPL70455.1	KPL72598.1	ADM99_15060	ADM99_05680	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KPL70455.1	KPL73008.1	ADM99_15060	ADM99_07300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KPL70455.1	KPL73479.1	ADM99_15060	ADM99_04670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
KPL70512.1	KPL70455.1	ADM99_15415	ADM99_15060	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
KPL70512.1	KPL71108.1	ADM99_15415	ADM99_12625	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KPL70512.1	KPL71113.1	ADM99_15415	ADM99_12650	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
KPL70512.1	KPL72147.1	ADM99_15415	ADM99_08365	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
KPL70512.1	KPL72598.1	ADM99_15415	ADM99_05680	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
KPL70512.1	KPL73008.1	ADM99_15415	ADM99_07300	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.976
KPL70512.1	KPL73479.1	ADM99_15415	ADM99_04670	Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
KPL70514.1	KPL70455.1	ADM99_15425	ADM99_15060	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
KPL70514.1	KPL71108.1	ADM99_15425	ADM99_12625	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KPL70514.1	KPL71113.1	ADM99_15425	ADM99_12650	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.828

expected number of edges:

18

PPI enrichment p-value:

1.48e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006325

Chromatin organization

8 of 171

1.62

2.78

5.60e-09

GO:0016571

Histone methylation

4 of 19

2.27

2.67

6.07e-06

GO:0031497

Chromatin assembly

5 of 50

1.95

2.6

2.26e-06

GO:0031507

Heterochromatin assembly

4 of 37

1.98

2.07

5.49e-05

GO:0034968

Histone lysine methylation

3 of 13

2.31

2.0

0.00016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035097

Histone methyltransferase complex

3 of 9

2.47

2.17

8.62e-05

GO:0000786

Nucleosome

3 of 10

2.42

2.16

8.62e-05

GO:0048188

Set1C/COMPASS complex

2 of 7

2.4

1.36

0.0030

GO:0005694

Chromosome

5 of 298

1.17

0.96

0.0017

GO:0005634

Nucleus

11 of 1915

0.7

0.65

1.34e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:300

Mixed, incl. PKMTs methylate histone lysines, and Nucleosome

8 of 57

2.09

5.14

6.46e-13

CL:303

Mixed, incl. PKMTs methylate histone lysines, and Nucleosome

7 of 44

2.15

4.9

8.98e-12

CL:305

PKMTs methylate histone lysines, and N-glycan antennae elongation in the medial/trans-Golgi

5 of 26

2.23

3.76

1.84e-08

CL:332

Histone-lysine N-methyltransferase activity, and Transcriptional Regulation by E2F6

3 of 12

2.34

2.17

7.50e-05

CL:334

Transcriptional Regulation by E2F6, and Heterochromatin boundary formation

2 of 5

2.55

1.35

0.0034

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4839726

Chromatin organization

6 of 77

1.84

2.89

1.35e-07

MAP-3247509

Chromatin modifying enzymes

6 of 77

1.84

2.89

1.35e-07

MAP-3214841

PKMTs methylate histone lysines

4 of 25

2.15

2.58

6.49e-06

MAP-2559580

Oxidative Stress Induced Senescence

3 of 12

2.34

2.09

0.00011

MAP-2559583

Cellular Senescence

3 of 31

1.93

1.5

0.00099

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

2 of 8

2.34

0.89

0.0235

GOCC:0035097

Histone methyltransferase complex

2 of 10

2.25

0.88

0.0235

GOCC:0000785

Chromatin

3 of 121

1.34

0.67

0.0350

GOCC:0005634

Nucleus

7 of 1123

0.74

0.46

0.0235

GOCC:0032991

Protein-containing complex

9 of 1912

0.62

0.42

0.0154

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0544

Nucleosome core

2 of 5

2.55

1.23

0.0057

KW-0853

WD repeat

3 of 97

1.44

0.9

0.0097

KW-0539

Nucleus

4 of 243

1.16

0.78

0.0092

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