STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrBAspartate carbamoyltransferase PyrB. (311 aa)    
Predicted Functional Partners:
carA
Carbamoyl-phosphate synthase small subunit CarA; Belongs to the CarA family.
 
 0.999
pyrF
Orotidine 5'-phosphate decarboxylase PyrF; Belongs to the OMP decarboxylase family.
  
  
 0.999
pyrE1
Orotate phosphoribosyltransferase PyrE1; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.999
pyrI
Aspartate carbamoyltransferase regulatory subunit PyrI; Involved in allosteric regulation of aspartate carbamoyltransferase.
 0.999
pyrC
Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 0.999
pyrD
Dihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate.
 
  
 0.999
carB
Carbamoyl-phosphate synthase large subunit CarB; Belongs to the CarB family.
 
 0.998
pyrK
Dihydroorotate dehydrogenase electron transfer subunit PyrK.
 
  
 0.997
asnB
Asparagine synthase (glutamine-hydrolyzing) AsnB.
  
 
 0.991
purA
Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.956
Your Current Organism:
Methanobrevibacter millerae
NCBI taxonomy Id: 230361
Other names: DSM 16643, M. millerae, Methanobrevibacter millerae Rea et al. 2007, Methanobrevibacter sp. ZA-10, OCM 820, strain ZA-10
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.