STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sm9_0298Archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. (140 aa)    
Predicted Functional Partners:
rtcB
tRNA-splicing ligase RtcB; Belongs to the RtcB family.
 
 0.953
sm9_0297
Hypothetical protein.
       0.773
prf1
Peptide chain release factor aRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.761
sm9_0299
Hypothetical protein.
       0.675
sm9_0300
Hypothetical protein.
       0.561
sm9_0296
Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication.
       0.533
mptE
Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
       0.520
sm9_0294
Hypothetical protein.
       0.447
ligT
2'-5' RNA ligase LigT; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
 
     0.424
mtnP
Methylthioadenosine phosphorylase MtnP; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
       0.418
Your Current Organism:
Methanobrevibacter millerae
NCBI taxonomy Id: 230361
Other names: DSM 16643, M. millerae, Methanobrevibacter millerae Rea et al. 2007, Methanobrevibacter sp. ZA-10, OCM 820, strain ZA-10
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