STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmBProteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (204 aa)    
Predicted Functional Partners:
psmA
Proteasome alpha subunit PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.986
sm9_0551
Hypothetical protein.
   
 0.947
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
  
 0.919
sm9_2192
Proteasome-activating nucleotidase.
  
 0.919
rpl40e
Ribosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.883
sm9_1303
ATPase AAA family.
 
 0.872
sm9_0330
ATPase.
  
 0.826
sm9_2050
RNA-metabolising metallo-beta-lactamase.
 
   
 0.778
nifS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
      0.704
eif1a
Translation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
  
 
 0.558
Your Current Organism:
Methanobrevibacter millerae
NCBI taxonomy Id: 230361
Other names: DSM 16643, M. millerae, Methanobrevibacter millerae Rea et al. 2007, Methanobrevibacter sp. ZA-10, OCM 820, strain ZA-10
Server load: low (20%) [HD]