Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CF15_01255Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
CF15_06275
AbrB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.992
CF15_01260
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.991
ilvD
Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
 0.987
CF15_01245
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.979
CF15_01250
Homoaconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.961
CF15_01550
Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.953
CF15_01565
Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.953
CF15_07525
2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.953
CF15_01560
Ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.952
Your Current Organism:
Pyrodictium occultum
NCBI taxonomy Id: 2309
Other names: DSM 2709, JCM 9393, NBRC 100438, P. occultum, strain PL-19
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