Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folEGTP cyclohydrolase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)    
Predicted Functional Partners:
CF15_05795
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.976
CF15_04115
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.962
CF15_04715
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.962
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
   
 0.960
CF15_07025
Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.952
CF15_04395
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.950
queE
Hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
  
 0.840
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
     
 0.683
CF15_00155
Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.657
CF15_01750
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.650
Your Current Organism:
Pyrodictium occultum
NCBI taxonomy Id: 2309
Other names: DSM 2709, JCM 9393, NBRC 100438, P. occultum, strain PL-19
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