Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobBNAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (254 aa)    
Predicted Functional Partners:
CF15_02365
Nicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD+ from nicotinamide ribonucleotide and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
  0.982
CF15_05860
Nicotinamide-nucleotide adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
  0.982
nadE
NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.971
nadK
Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.970
CF15_04535
Diadenosine tetraphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
  0.719
CF15_04085
Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.709
CF15_04225
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.675
CF15_05755
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.590
CF15_04545
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.543
CF15_03415
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.521
Your Current Organism:
Pyrodictium occultum
NCBI taxonomy Id: 2309
Other names: DSM 2709, JCM 9393, NBRC 100438, P. occultum, strain PL-19
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