CVT26_014177 protein (Gymnopilus dilepis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CVT26_014177

Uncharacterized protein. (1243 aa)

Predicted Functional Partners:

TRM8

0.886

CVT26_000768

0.740

CVT26_002699

0.639

CVT26_008677

0.638

CVT26_006520

0.617

CVT26_007417

0.616

CVT26_009085

0.560

CVT26_007196

0.557

CVT26_004150

0.557

CVT26_010718

0.520

Your Current Organism:

Gymnopilus dilepis

NCBI taxonomy Id: 231916
Other names: Agaricus dilepis, G. dilepis

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT26_000768	CVT26_004150	A0A409Y2M7	A0A409W755	PX domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.408
CVT26_000768	CVT26_007417	A0A409Y2M7	A0A409VN55	PX domain-containing protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.418
CVT26_000768	CVT26_008677	A0A409Y2M7	A0A409XY06	PX domain-containing protein.	PXA domain-containing protein.	0.658
CVT26_000768	CVT26_009085	A0A409Y2M7	A0A409WUJ1	PX domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.452
CVT26_000768	CVT26_014177	A0A409Y2M7	A0A409VU96	PX domain-containing protein.	Uncharacterized protein.	0.740
CVT26_002699	CVT26_006520	A0A409VE53	A0A409Y3L1	Uncharacterized protein.	Uncharacterized protein.	0.985
CVT26_002699	CVT26_008677	A0A409VE53	A0A409XY06	Uncharacterized protein.	PXA domain-containing protein.	0.650
CVT26_002699	CVT26_014177	A0A409VE53	A0A409VU96	Uncharacterized protein.	Uncharacterized protein.	0.639
CVT26_004150	CVT26_000768	A0A409W755	A0A409Y2M7	t-SNARE coiled-coil homology domain-containing protein.	PX domain-containing protein.	0.408
CVT26_004150	CVT26_006520	A0A409W755	A0A409Y3L1	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein.	0.566
CVT26_004150	CVT26_007196	A0A409W755	A0A409W097	t-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.803
CVT26_004150	CVT26_007417	A0A409W755	A0A409VN55	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.989
CVT26_004150	CVT26_008677	A0A409W755	A0A409XY06	t-SNARE coiled-coil homology domain-containing protein.	PXA domain-containing protein.	0.557
CVT26_004150	CVT26_009085	A0A409W755	A0A409WUJ1	t-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.969
CVT26_004150	CVT26_010718	A0A409W755	A0A409VIC0	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.465
CVT26_004150	CVT26_014177	A0A409W755	A0A409VU96	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein.	0.557
CVT26_006520	CVT26_002699	A0A409Y3L1	A0A409VE53	Uncharacterized protein.	Uncharacterized protein.	0.985
CVT26_006520	CVT26_004150	A0A409Y3L1	A0A409W755	Uncharacterized protein.	t-SNARE coiled-coil homology domain-containing protein.	0.566
CVT26_006520	CVT26_007196	A0A409Y3L1	A0A409W097	Uncharacterized protein.	t-SNARE coiled-coil homology domain-containing protein.	0.610
CVT26_006520	CVT26_007417	A0A409Y3L1	A0A409VN55	Uncharacterized protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.910

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.901

expected number of edges:

11

PPI enrichment p-value:

0.000451

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

3 of 5

2.28

1.79

0.00041

GO:0033554

Cellular response to stress

6 of 78

1.39

1.47

8.68e-05

GO:0006281

DNA repair

5 of 54

1.47

1.43

0.00026

GO:0009432

SOS response

3 of 15

1.8

1.22

0.0034

GO:0006308

DNA catabolic process

2 of 5

2.1

1.01

0.0128

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004536

Deoxyribonuclease activity

4 of 23

1.74

1.5

0.00063

GO:0008855

Exodeoxyribonuclease VII activity

2 of 2

2.5

1.16

0.0076

GO:0009381

Excinuclease ABC activity

2 of 3

2.33

1.11

0.0090

GO:0140097

Catalytic activity, acting on DNA

5 of 105

1.18

0.88

0.0039

GO:0140640

Catalytic activity, acting on a nucleic acid

6 of 242

0.9

0.63

0.0071

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009318

Exodeoxyribonuclease VII complex

2 of 2

2.5

1.32

0.0037

GO:0009380

Excinuclease repair complex

2 of 3

2.33

1.28

0.0041

GO:1902494

Catalytic complex

5 of 80

1.3

1.21

0.00043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:617

DNA damage, and UvrD/REP helicase N-terminal domain

3 of 21

1.66

0.72

0.0372

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tor03420

Nucleotide excision repair

3 of 9

2.03

1.66

0.00053

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990391

DNA repair complex

3 of 6

2.2

1.69

0.00058

GOCC:0009318

Exodeoxyribonuclease VII complex

2 of 2

2.5

1.14

0.0081

GOCC:0009380

Excinuclease repair complex

2 of 3

2.33

1.11

0.0090

GOCC:1902494

Catalytic complex

5 of 192

0.92

0.6

0.0141

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

5 of 29

1.74

2.22

6.15e-06

KW-0742

SOS response

3 of 10

1.98

1.67

0.00047

KW-0267

Excision nuclease

2 of 3

2.33

1.24

0.0049

KW-0228

DNA excision

2 of 3

2.33

1.24

0.0049

KW-0269

Exonuclease

2 of 15

1.63

0.74

0.0341

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02151

UvrB/uvrC motif

2 of 2

2.5

0.84

0.0295

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 8

1.9

0.7

0.0465

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