CVT26_011496 protein (Gymnopilus dilepis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CVT26_011496

Uncharacterized protein. (176 aa)

Predicted Functional Partners:

CVT26_001651

0.872

CVT26_014368

0.821

CVT26_008852

0.730

CVT26_000983

0.730

CVT26_006130

0.710

CVT26_006666

0.700

CVT26_009908

0.696

CVT26_009760

0.641

CVT26_014669

0.641

CVT26_010128

0.612

Your Current Organism:

Gymnopilus dilepis

NCBI taxonomy Id: 231916
Other names: Agaricus dilepis, G. dilepis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT26_000983	CVT26_001651	A0A409YL51	A0A409VTT7	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.808
CVT26_000983	CVT26_006130	A0A409YL51	A0A409YKH5	Uncharacterized protein.	CBF domain-containing protein.	0.703
CVT26_000983	CVT26_006666	A0A409YL51	A0A409Y2S0	Uncharacterized protein.	RNA helicase.	0.515
CVT26_000983	CVT26_008852	A0A409YL51	A0A409WP56	Uncharacterized protein.	Npa1 domain-containing protein.	0.899
CVT26_000983	CVT26_009760	A0A409YL51	A0A409VKI6	Uncharacterized protein.	Uncharacterized protein; Belongs to the OSBP family.	0.505
CVT26_000983	CVT26_009908	A0A409YL51	A0A409YBZ8	Uncharacterized protein.	Uncharacterized protein.	0.600
CVT26_000983	CVT26_010128	A0A409YL51	A0A409YS84	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.650
CVT26_000983	CVT26_011496	A0A409YL51	A0A409VXR0	Uncharacterized protein.	Uncharacterized protein.	0.730
CVT26_001651	CVT26_000983	A0A409VTT7	A0A409YL51	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.808
CVT26_001651	CVT26_006130	A0A409VTT7	A0A409YKH5	Uncharacterized protein; Belongs to the DEAD box helicase family.	CBF domain-containing protein.	0.826
CVT26_001651	CVT26_006666	A0A409VTT7	A0A409Y2S0	Uncharacterized protein; Belongs to the DEAD box helicase family.	RNA helicase.	0.725
CVT26_001651	CVT26_008852	A0A409VTT7	A0A409WP56	Uncharacterized protein; Belongs to the DEAD box helicase family.	Npa1 domain-containing protein.	0.808
CVT26_001651	CVT26_009760	A0A409VTT7	A0A409VKI6	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the OSBP family.	0.762
CVT26_001651	CVT26_009908	A0A409VTT7	A0A409YBZ8	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.841
CVT26_001651	CVT26_010128	A0A409VTT7	A0A409YS84	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.746
CVT26_001651	CVT26_011496	A0A409VTT7	A0A409VXR0	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.872
CVT26_001651	CVT26_014368	A0A409VTT7	A0A409Y818	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.676
CVT26_001651	CVT26_014669	A0A409VTT7	A0A409W3D5	Uncharacterized protein; Belongs to the DEAD box helicase family.	TRASH domain-containing protein.	0.607
CVT26_006130	CVT26_000983	A0A409YKH5	A0A409YL51	CBF domain-containing protein.	Uncharacterized protein.	0.703
CVT26_006130	CVT26_001651	A0A409YKH5	A0A409VTT7	CBF domain-containing protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.826

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

11

average node degree:

2

avg. local clustering coefficient:

0.911

expected number of edges:

10

PPI enrichment p-value:

0.459

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

7 of 49

2.34

5.28

9.25e-12

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

6 of 51

2.25

4.28

1.21e-09

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

5 of 23

2.52

4.27

5.27e-09

GO:0072593

Reactive oxygen species metabolic process

3 of 60

1.88

1.21

0.0041

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

5 of 33

2.36

3.67

5.53e-08

GO:0016491

Oxidoreductase activity

6 of 654

1.15

1.06

0.00038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

6 of 41

2.35

4.73

2.11e-10

GO:0005743

Mitochondrial inner membrane

8 of 349

1.54

2.74

8.05e-10

GO:0031966

Mitochondrial membrane

9 of 512

1.43

2.45

3.46e-10

GO:0005739

Mitochondrion

11 of 1214

1.14

1.64

2.11e-10

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33435522

(2021) Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.

10 of 105

2.16

6.48

1.88e-16

PMID:27226634

(2016) NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I.

5 of 31

2.39

3.13

8.76e-07

PMID:24089531

(2013) NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I.

5 of 31

2.39

3.13

8.76e-07

PMID:33882309

(2021) NDUFS3 depletion permits complex I maturation and reveals TMEM126AOPA7 as an assembly factor binding the ND4-module intermediate.

5 of 40

2.28

2.97

1.42e-06

PMID:27743346

(2016) Amazing structure of respirasome: unveiling the secrets of cell respiration.

4 of 23

2.42

2.33

3.92e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1916

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., and Proton motive force-driven ATP synthesis

11 of 115

2.16

7.7

1.04e-20

CL:2120

Complex I biogenesis

5 of 7

3.04

5.73

2.50e-11

CL:1930

NADH dehydrogenase complex

6 of 37

2.39

5.03

5.69e-11

CL:1932

NADH dehydrogenase complex

4 of 29

2.32

3.01

1.28e-06

CL:1975

Mitochondrial electron transport, NADH to ubiquinone

2 of 5

2.79

1.44

0.0024

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gga00190

Oxidative phosphorylation

6 of 110

1.92

3.44

7.12e-09

gga01100

Metabolic pathways

6 of 1204

0.88

0.66

0.0039

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

GGA-6799198

Complex I biogenesis

11 of 51

2.52

10.8

1.08e-24

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005743

Mitochondrial inner membrane

7 of 192

1.75

3.07

7.38e-09

GOCC:0070469

Respirasome

4 of 63

1.99

2.32

1.47e-05

GOCC:0005747

Mitochondrial respiratory chain complex I

3 of 22

2.32

2.14

8.35e-05

GOCC:0005739

Mitochondrion

10 of 789

1.29

1.99

9.36e-10

GOCC:1902495

Transmembrane transporter complex

3 of 158

1.46

0.89

0.0112

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

3 of 23

2.3

1.92

0.00023

KW-1278

Translocase

3 of 37

2.09

1.73

0.00043

KW-0830

Ubiquinone

2 of 9

2.53

1.49

0.0018

KW-0520

NAD

3 of 73

1.8

1.37

0.0015

KW-0496

Mitochondrion

3 of 207

1.34

0.75

0.0209

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