CVT26_003774 protein (Gymnopilus dilepis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CVT26_003774

Uncharacterized protein. (251 aa)

Predicted Functional Partners:

BNA5

0.988

CVT26_007100

0.734

CVT26_015345

0.734

CVT26_009715

0.720

CVT26_006922

0.697

CVT26_012039

0.688

CVT26_008038

0.688

CVT26_012381

0.654

CVT26_009478

0.647

CVT26_015940

0.639

Your Current Organism:

Gymnopilus dilepis

NCBI taxonomy Id: 231916
Other names: Agaricus dilepis, G. dilepis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA5	CVT26_003774	A0A409W0W7	A0A409W1N8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.988
BNA5	CVT26_015940	A0A409W0W7	A0A409XYJ4	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.616
CVT26_003774	BNA5	A0A409W1N8	A0A409W0W7	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.988
CVT26_003774	CVT26_006922	A0A409W1N8	A0A409W122	Uncharacterized protein.	Polyketide_cyc domain-containing protein.	0.697
CVT26_003774	CVT26_007100	A0A409W1N8	A0A409VNR3	Uncharacterized protein.	CN hydrolase domain-containing protein.	0.734
CVT26_003774	CVT26_008038	A0A409W1N8	A0A409YJL2	Uncharacterized protein.	Uncharacterized protein.	0.688
CVT26_003774	CVT26_009478	A0A409W1N8	A0A409VK06	Uncharacterized protein.	Uncharacterized protein.	0.647
CVT26_003774	CVT26_009715	A0A409W1N8	A0A409WCN1	Uncharacterized protein.	FMN_red domain-containing protein.	0.720
CVT26_003774	CVT26_012039	A0A409W1N8	A0A409VYC8	Uncharacterized protein.	Malate synthase; Belongs to the malate synthase family.	0.688
CVT26_003774	CVT26_012381	A0A409W1N8	A0A409WAN7	Uncharacterized protein.	Uncharacterized protein.	0.654
CVT26_003774	CVT26_015345	A0A409W1N8	A0A409W4A1	Uncharacterized protein.	CN hydrolase domain-containing protein.	0.734
CVT26_003774	CVT26_015940	A0A409W1N8	A0A409XYJ4	Uncharacterized protein.	Uncharacterized protein.	0.639
CVT26_006922	CVT26_003774	A0A409W122	A0A409W1N8	Polyketide_cyc domain-containing protein.	Uncharacterized protein.	0.697
CVT26_007100	CVT26_003774	A0A409VNR3	A0A409W1N8	CN hydrolase domain-containing protein.	Uncharacterized protein.	0.734
CVT26_007100	CVT26_008038	A0A409VNR3	A0A409YJL2	CN hydrolase domain-containing protein.	Uncharacterized protein.	0.698
CVT26_007100	CVT26_009478	A0A409VNR3	A0A409VK06	CN hydrolase domain-containing protein.	Uncharacterized protein.	0.621
CVT26_007100	CVT26_012039	A0A409VNR3	A0A409VYC8	CN hydrolase domain-containing protein.	Malate synthase; Belongs to the malate synthase family.	0.677
CVT26_007100	CVT26_012381	A0A409VNR3	A0A409WAN7	CN hydrolase domain-containing protein.	Uncharacterized protein.	0.885
CVT26_008038	CVT26_003774	A0A409YJL2	A0A409W1N8	Uncharacterized protein.	Uncharacterized protein.	0.688
CVT26_008038	CVT26_007100	A0A409YJL2	A0A409VNR3	Uncharacterized protein.	CN hydrolase domain-containing protein.	0.698

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.787

expected number of edges:

11

PPI enrichment p-value:

0.0608

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007507

Heart development

2 of 3

2.91

0.91

0.0226

GO:0000743

Nuclear migration involved in conjugation with cellular fusion

2 of 4

2.78

0.91

0.0226

GO:0000132

Establishment of mitotic spindle orientation

2 of 7

2.54

0.9

0.0226

GO:0000747

Conjugation with cellular fusion

3 of 41

1.95

0.87

0.0226

GO:0007017

Microtubule-based process

3 of 128

1.45

0.63

0.0491

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032977

Membrane insertase activity

3 of 10

2.56

1.96

0.00024

GO:0005200

Structural constituent of cytoskeleton

2 of 5

2.68

1.14

0.0086

GO:0051010

Microtubule plus-end binding

2 of 14

2.24

0.83

0.0295

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005875

Microtubule associated complex

7 of 32

2.42

6.04

3.21e-13

GO:0005869

Dynactin complex

5 of 7

2.94

5.54

4.90e-11

GO:0015629

Actin cytoskeleton

6 of 123

1.77

2.87

6.12e-08

GO:0072546

EMC complex

3 of 11

2.52

2.5

2.03e-05

GO:0005856

Cytoskeleton

8 of 367

1.42

2.2

1.76e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5936

Dynactin complex, and Dynein complex

8 of 13

2.87

9.05

3.39e-18

CL:5951

Dynactin complex, and Cell projection assembly

4 of 5

2.99

4.35

9.76e-09

CL:19836

EMC complex

3 of 10

2.56

2.41

3.26e-05

CL:5938

Dynein heavy chain binding, and Dynamitin

2 of 5

2.68

1.39

0.0029

CL:19838

EMC complex

2 of 5

2.68

1.39

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6811436

COPI-independent Golgi-to-ER retrograde traffic

6 of 15

2.68

5.95

3.17e-12

MAP-2132295

MHC class II antigen presentation

6 of 46

2.2

4.39

3.93e-10

MAP-6807878

COPI-mediated anterograde transport

7 of 83

2.01

4.25

8.07e-11

MAP-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

6 of 52

2.14

4.23

5.84e-10

MAP-199977

ER to Golgi Anterograde Transport

7 of 141

1.78

3.35

1.14e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005869

Dynactin complex

5 of 7

2.94

5.49

6.08e-11

GOCC:0005875

Microtubule associated complex

7 of 58

2.16

4.83

1.79e-11

GOCC:0015629

Actin cytoskeleton

6 of 113

1.81

2.98

4.65e-08

GOCC:0005856

Cytoskeleton

8 of 335

1.46

2.33

1.07e-08

GOCC:0072546

ER membrane protein complex

2 of 10

2.38

1.21

0.0059

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12455

Dynein associated protein

2 of 2

3.08

1.19

0.0071

PF00132

Bacterial transferase hexapeptide (six repeats)

2 of 5

2.68

1.05

0.0123

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047125

Dynactin subunit 5

2 of 2

3.08

0.96

0.0186

IPR036859

CAP Gly-rich domain superfamily

2 of 4

2.78

0.96

0.0186

IPR022157

Dynein associated protein

2 of 2

3.08

0.96

0.0186

IPR000938

CAP Gly-rich domain

2 of 4

2.78

0.96

0.0186

IPR011004

Trimeric LpxA-like superfamily

2 of 8

2.48

0.85

0.0279

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01052

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including ...

2 of 4

2.78

1.32

0.0040

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (10%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About