CVT26_007116 protein (Gymnopilus dilepis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

CVT26_007116

TPR_REGION domain-containing protein. (646 aa)

Predicted Functional Partners:

CVT26_010053

0.995

CVT26_015854

0.995

CVT26_005568

0.995

CVT26_000250

0.994

CVT26_001139

0.994

CVT26_002094

0.985

CVT26_002978

0.982

CVT26_012589

0.980

CVT26_004515

0.975

CVT26_009233

0.975

Your Current Organism:

Gymnopilus dilepis

NCBI taxonomy Id: 231916
Other names: Agaricus dilepis, G. dilepis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT26_000250	CVT26_001139	A0A409VGC9	A0A409YMX3	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.999
CVT26_000250	CVT26_002094	A0A409VGC9	A0A409VEV6	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.999
CVT26_000250	CVT26_002978	A0A409VGC9	A0A409WT20	TPR_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.991
CVT26_000250	CVT26_004515	A0A409VGC9	A0A409WEX3	TPR_REGION domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.985
CVT26_000250	CVT26_005568	A0A409VGC9	A0A409XZU6	TPR_REGION domain-containing protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.999
CVT26_000250	CVT26_007116	A0A409VGC9	A0A409WQA8	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.994
CVT26_000250	CVT26_009233	A0A409VGC9	A0A409YRM3	TPR_REGION domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.985
CVT26_000250	CVT26_010053	A0A409VGC9	A0A409VWJ0	TPR_REGION domain-containing protein.	APC1_C domain-containing protein.	0.999
CVT26_000250	CVT26_012589	A0A409VGC9	A0A409YPR5	TPR_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.992
CVT26_000250	CVT26_015854	A0A409VGC9	A0A409XYB6	TPR_REGION domain-containing protein.	RING-type domain-containing protein.	0.999
CVT26_001139	CVT26_000250	A0A409YMX3	A0A409VGC9	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.999
CVT26_001139	CVT26_002094	A0A409YMX3	A0A409VEV6	Uncharacterized protein.	Uncharacterized protein.	0.999
CVT26_001139	CVT26_002978	A0A409YMX3	A0A409WT20	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.992
CVT26_001139	CVT26_004515	A0A409YMX3	A0A409WEX3	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.988
CVT26_001139	CVT26_005568	A0A409YMX3	A0A409XZU6	Uncharacterized protein.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.999
CVT26_001139	CVT26_007116	A0A409YMX3	A0A409WQA8	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.994
CVT26_001139	CVT26_009233	A0A409YMX3	A0A409YRM3	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.987
CVT26_001139	CVT26_010053	A0A409YMX3	A0A409VWJ0	Uncharacterized protein.	APC1_C domain-containing protein.	0.999
CVT26_001139	CVT26_012589	A0A409YMX3	A0A409YPR5	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.991
CVT26_001139	CVT26_015854	A0A409YMX3	A0A409XYB6	Uncharacterized protein.	RING-type domain-containing protein.	0.999

page 1 of 6

Network Stats

number of nodes:

7

number of edges:

13

average node degree:

3.71

avg. local clustering coefficient:

0.924

expected number of edges:

6

PPI enrichment p-value:

0.00911

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

9 of 21

2.89

10.62

2.13e-21

GO:1902600

Proton transmembrane transport

11 of 103

2.29

8.67

9.50e-22

GO:0046034

ATP metabolic process

10 of 92

2.3

8.07

1.05e-19

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

5 of 11

2.92

5.76

1.73e-11

GO:0007035

Vacuolar acidification

2 of 19

2.28

1.17

0.0067

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

11 of 104

2.29

8.78

3.44e-22

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 11

2.82

4.12

2.16e-08

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 28

2.12

0.85

0.0257

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

9 of 15

3.04

11.77

3.05e-23

GO:0016469

Proton-transporting two-sector ATPase complex

11 of 49

2.61

11.67

7.93e-26

GO:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

6 of 22

2.7

6.4

3.95e-13

GO:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

5 of 9

3.01

6.1

4.70e-12

GO:0033178

Proton-transporting two-sector ATPase complex, catalytic domain

4 of 19

2.58

3.94

3.15e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25925

Formation of ATP by chemiosmotic coupling

9 of 17

2.99

11.09

4.89e-22

CL:25932

Mitochondrial proton-transporting ATP synthase complex

7 of 7

3.26

9.39

4.52e-18

CL:31860

Vacuolar proton-transporting V-type ATPase, V1 domain

2 of 6

2.78

1.37

0.0032

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 189

2.03

6.87

1.39e-20

map01100

Metabolic pathways

11 of 2959

0.83

0.9

6.98e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

9 of 19

2.94

11.04

4.23e-22

MAP-8949613

Cristae formation

9 of 30

2.74

10.05

6.48e-21

MAP-1592230

Mitochondrial biogenesis

9 of 54

2.48

8.54

4.82e-19

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

9 of 130

2.1

6.09

6.21e-16

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

9 of 191

1.93

5.06

1.42e-14

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001630

Right ventricle

5 of 133

1.84

3.0

5.70e-08

BTO:0001703

Right atrium

2 of 102

1.55

1.17

0.0025

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016469

Proton-transporting two-sector ATPase complex

11 of 42

2.68

12.19

2.10e-26

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 25

2.82

10.53

1.46e-21

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

6 of 15

2.86

6.79

1.36e-13

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

5 of 8

3.06

6.09

5.40e-12

GOCC:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

4 of 4

3.26

5.02

7.24e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

8 of 25

2.77

9.09

1.19e-18

KW-0066

ATP synthesis

3 of 5

3.04

3.41

5.89e-07

KW-0139

CF(1)

2 of 4

2.96

1.96

0.00028

KW-0496

Mitochondrion

3 of 158

1.54

1.07

0.0046

KW-0999

Mitochondrion inner membrane

2 of 51

1.86

0.9

0.0183

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05873

ATP synthase D chain, mitochondrial (ATP5H)

2 of 2

3.26

1.36

0.0036

PF00006

ATP synthase alpha/beta family, nucleotide-binding domain

2 of 4

2.96

1.3

0.0045

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 6

2.78

1.24

0.0056

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