CVT26_015003 protein (Gymnopilus dilepis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

CVT26_015003

Uncharacterized protein. (2436 aa)

Predicted Functional Partners:

CVT26_000125

0.541

CVT26_007677

0.442

CVT26_010504

0.442

CVT26_005086

0.418

CVT26_010800

0.413

CVT26_015471

0.413

CVT26_015568

0.413

CVT26_015567

0.413

CVT26_012230

0.413

CVT26_008997

0.413

Your Current Organism:

Gymnopilus dilepis

NCBI taxonomy Id: 231916
Other names: Agaricus dilepis, G. dilepis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT26_000125	CVT26_015003	A0A409VGY1	A0A409YP80	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Uncharacterized protein.	0.541
CVT26_005086	CVT26_015003	A0A409Y0C6	A0A409YP80	Uncharacterized protein; Belongs to the argonaute family.	Uncharacterized protein.	0.418
CVT26_007677	CVT26_015003	A0A409WT31	A0A409YP80	Uncharacterized protein.	Uncharacterized protein.	0.442
CVT26_008997	CVT26_015003	A0A409YR93	A0A409YP80	Piwi domain-containing protein.	Uncharacterized protein.	0.413
CVT26_010504	CVT26_015003	A0A409Y0E5	A0A409YP80	Uncharacterized protein.	Uncharacterized protein.	0.442
CVT26_010800	CVT26_015003	A0A409VIE3	A0A409YP80	Uncharacterized protein.	Uncharacterized protein.	0.413
CVT26_012230	CVT26_015003	A0A409YQ58	A0A409YP80	Piwi domain-containing protein.	Uncharacterized protein.	0.413
CVT26_015003	CVT26_000125	A0A409YP80	A0A409VGY1	Uncharacterized protein.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.541
CVT26_015003	CVT26_005086	A0A409YP80	A0A409Y0C6	Uncharacterized protein.	Uncharacterized protein; Belongs to the argonaute family.	0.418
CVT26_015003	CVT26_007677	A0A409YP80	A0A409WT31	Uncharacterized protein.	Uncharacterized protein.	0.442
CVT26_015003	CVT26_008997	A0A409YP80	A0A409YR93	Uncharacterized protein.	Piwi domain-containing protein.	0.413
CVT26_015003	CVT26_010504	A0A409YP80	A0A409Y0E5	Uncharacterized protein.	Uncharacterized protein.	0.442
CVT26_015003	CVT26_010800	A0A409YP80	A0A409VIE3	Uncharacterized protein.	Uncharacterized protein.	0.413
CVT26_015003	CVT26_012230	A0A409YP80	A0A409YQ58	Uncharacterized protein.	Piwi domain-containing protein.	0.413
CVT26_015003	CVT26_015471	A0A409YP80	A0A409WA60	Uncharacterized protein.	Uncharacterized protein.	0.413
CVT26_015003	CVT26_015567	A0A409YP80	A0A409XYS0	Uncharacterized protein.	Uncharacterized protein.	0.413
CVT26_015003	CVT26_015568	A0A409YP80	A0A409XYP8	Uncharacterized protein.	Piwi domain-containing protein.	0.413
CVT26_015471	CVT26_015003	A0A409WA60	A0A409YP80	Uncharacterized protein.	Uncharacterized protein.	0.413
CVT26_015567	CVT26_015003	A0A409XYS0	A0A409YP80	Uncharacterized protein.	Uncharacterized protein.	0.413
CVT26_015568	CVT26_015003	A0A409XYP8	A0A409YP80	Piwi domain-containing protein.	Uncharacterized protein.	0.413

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

5 of 81

1.2

0.94

0.0035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2296

UbiC transcription regulator-associated

3 of 5

2.19

1.65

0.0011

CL:1696

Duplicated hybrid motif, and Glucose permease domain IIB

3 of 12

1.81

1.29

0.0034

CL:1699

Glucose permease domain IIB

2 of 6

1.94

0.89

0.0256

CL:1685

Import into cell, and Hydrolase activity, hydrolyzing O-glycosyl compounds

4 of 120

0.94

0.53

0.0377

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0598

Phosphotransferase system

3 of 27

1.46

1.02

0.0066

KW-0805

Transcription regulation

5 of 96

1.13

0.91

0.0026

KW-0762

Sugar transport

3 of 35

1.35

0.89

0.0107

KW-0238

DNA-binding

5 of 146

0.95

0.69

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00367

Phosphotransferase system, EIIB

3 of 12

1.81

1.18

0.0059

PF02378

Phosphotransferase system, EIIC

3 of 24

1.51

0.86

0.0186

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR028978

Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain superfamily

4 of 11

1.98

2.01

0.00013

IPR011663

UbiC transcription regulator-associated

4 of 11

1.98

2.01

0.00013

IPR000524

Transcription regulator HTH, GntR

4 of 14

1.87

1.94

0.00013

IPR036878

Glucose permease domain IIB

3 of 12

1.81

1.25

0.0042

IPR018113

Phosphotransferase system EIIB, cysteine phosphorylation site

3 of 12

1.81

1.25

0.0042

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00866

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.

4 of 11

1.98

2.46

1.19e-05

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

4 of 14

1.87

2.34

1.33e-05

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