CVT26_010118 protein (Gymnopilus dilepis) - STRING interaction network

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

CVT26_010118

Uncharacterized protein. (233 aa)

Predicted Functional Partners:

CVT26_007373

0.738

CVT26_007558

0.687

CVT26_002032

0.665

CVT26_008535

0.659

CVT26_014135

0.658

CVT26_005775

0.657

CVT26_003630

0.657

CVT26_005084

0.652

CVT26_003394

0.650

CVT26_014211

0.639

Your Current Organism:

Gymnopilus dilepis

NCBI taxonomy Id: 231916
Other names: Agaricus dilepis, G. dilepis

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT26_002032	CVT26_003394	A0A409VBU7	A0A409Y5H3	Uncharacterized protein.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.750
CVT26_002032	CVT26_010118	A0A409VBU7	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.665
CVT26_002032	CVT26_014211	A0A409VBU7	A0A409VUA8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.589
CVT26_003394	CVT26_002032	A0A409Y5H3	A0A409VBU7	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	Uncharacterized protein.	0.750
CVT26_003394	CVT26_010118	A0A409Y5H3	A0A409YS76	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	Uncharacterized protein.	0.650
CVT26_003394	CVT26_014211	A0A409Y5H3	A0A409VUA8	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	Ubiquitin-like domain-containing protein.	0.560
CVT26_003630	CVT26_008535	A0A409VR42	A0A409XXL8	Uncharacterized protein.	Uncharacterized protein.	0.976
CVT26_003630	CVT26_010118	A0A409VR42	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.657
CVT26_003630	CVT26_014135	A0A409VR42	A0A409VUC5	Uncharacterized protein.	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.827
CVT26_005084	CVT26_010118	A0A409Y0G8	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.652
CVT26_005775	CVT26_008535	A0A409VPM0	A0A409XXL8	Uncharacterized protein.	Uncharacterized protein.	0.976
CVT26_005775	CVT26_010118	A0A409VPM0	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.657
CVT26_005775	CVT26_014135	A0A409VPM0	A0A409VUC5	Uncharacterized protein.	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.827
CVT26_007373	CVT26_010118	A0A409VP24	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.738
CVT26_007373	CVT26_014211	A0A409VP24	A0A409VUA8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.757
CVT26_007558	CVT26_010118	A0A409W855	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.687
CVT26_007558	CVT26_014211	A0A409W855	A0A409VUA8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.722
CVT26_008535	CVT26_003630	A0A409XXL8	A0A409VR42	Uncharacterized protein.	Uncharacterized protein.	0.976
CVT26_008535	CVT26_005775	A0A409XXL8	A0A409VPM0	Uncharacterized protein.	Uncharacterized protein.	0.976
CVT26_008535	CVT26_010118	A0A409XXL8	A0A409YS76	Uncharacterized protein.	Uncharacterized protein.	0.659

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006914

Autophagy

7 of 78

1.92

3.58

2.43e-09

GO:0030242

Autophagy of peroxisome

3 of 4

2.84

2.43

3.66e-05

GO:0016236

Macroautophagy

4 of 39

1.97

2.01

7.51e-05

GO:0015031

Protein transport

6 of 431

1.11

0.96

0.00079

GO:0006810

Transport

9 of 1132

0.86

0.8

8.39e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

4 of 4

2.96

4.01

4.19e-08

GO:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

4 of 4

2.96

4.01

4.19e-08

GO:0005770

Late endosome

4 of 41

1.95

2.36

9.70e-06

GO:0005768

Endosome

6 of 160

1.54

2.16

7.62e-07

GO:0031410

Cytoplasmic vesicle

8 of 297

1.39

2.08

4.19e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11291

Autophagy - other, and SNARE complex assembly

8 of 34

2.33

6.44

1.03e-14

CL:11297

Autophagy, and Phosphatidylinositol 3-kinase complex, class III, type I

5 of 14

2.52

4.53

1.45e-09

CL:8217

Mixed, incl. HOPS complex, and VPS9 domain

3 of 29

1.98

1.57

0.00075

CL:11299

Ubiquitin-like autophagy protein Apg12 , and Autophagy

2 of 7

2.42

1.22

0.0056

CL:8218

HOPS complex, and phosphatidylinositol-5-phosphate binding

2 of 18

2.01

0.84

0.0265

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

5 of 38

2.08

3.37

5.96e-08

map04138

Autophagy - yeast

6 of 97

1.75

2.85

5.96e-08

map04145

Phagosome

3 of 81

1.53

1.08

0.0041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9612973

Autophagy

7 of 78

1.92

3.75

6.84e-10

MAP-1632852

Macroautophagy

7 of 78

1.92

3.75

6.84e-10

MAP-1483255

PI Metabolism

4 of 36

2.01

2.27

2.10e-05

MAP-5668599

RHO GTPases Activate NADPH Oxidases

3 of 11

2.4

2.17

8.02e-05

MAP-1660517

Synthesis of PIPs at the late endosome membrane

3 of 11

2.4

2.17

8.02e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

5 of 6

2.88

5.16

2.39e-10

GOCC:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

4 of 4

2.96

4.28

1.31e-08

GOCC:0044232

Organelle membrane contact site

3 of 25

2.04

1.75

0.00034

GOCC:0000421

Autophagosome membrane

2 of 4

2.66

1.53

0.0016

GOCC:0071561

Nucleus-vacuole junction

2 of 5

2.57

1.47

0.0020

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

2 of 2

2.96

1.58

0.0014

KW-0072

Autophagy

2 of 14

2.12

0.98

0.0144

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04110

Ubiquitin-like autophagy protein Apg12

2 of 3

2.79

1.1

0.0100

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045162

Serine/threonine-protein kinase Vps15-like

2 of 2

2.96

0.98

0.0172

IPR004241

Autophagy protein Atg8 ubiquitin-like

2 of 2

2.96

0.98

0.0172

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