node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobD2 | hisA | TKV_c03170 | TKV_c18430 | Putative threonine-phosphate decarboxylase CobD. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | 0.788 |
cobD2 | hisB | TKV_c03170 | TKV_c18450 | Putative threonine-phosphate decarboxylase CobD. | Imidazoleglycerol-phosphate dehydratase HisB. | 0.927 |
cobD2 | hisD | TKV_c03170 | TKV_c18470 | Putative threonine-phosphate decarboxylase CobD. | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.930 |
cobD2 | hisF | TKV_c03170 | TKV_c18420 | Putative threonine-phosphate decarboxylase CobD. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.853 |
cobD2 | hisG | TKV_c03170 | TKV_c18480 | Putative threonine-phosphate decarboxylase CobD. | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.757 |
cobD2 | hisH | TKV_c03170 | TKV_c18440 | Putative threonine-phosphate decarboxylase CobD. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.826 |
cobD2 | hisI | TKV_c03170 | TKV_c18410 | Putative threonine-phosphate decarboxylase CobD. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.998 |
cobD2 | hisZ | TKV_c03170 | TKV_c18490 | Putative threonine-phosphate decarboxylase CobD. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.733 |
hisA | cobD2 | TKV_c18430 | TKV_c03170 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Putative threonine-phosphate decarboxylase CobD. | 0.788 |
hisA | hisB | TKV_c18430 | TKV_c18450 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Imidazoleglycerol-phosphate dehydratase HisB. | 0.997 |
hisA | hisC | TKV_c18430 | TKV_c18460 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Histidinol-phosphate aminotransferase HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.960 |
hisA | hisD | TKV_c18430 | TKV_c18470 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisF | TKV_c18430 | TKV_c18420 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | TKV_c18430 | TKV_c18480 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.997 |
hisA | hisH | TKV_c18430 | TKV_c18440 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | TKV_c18430 | TKV_c18410 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | TKV_c18430 | TKV_c18490 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.956 |
hisB | cobD2 | TKV_c18450 | TKV_c03170 | Imidazoleglycerol-phosphate dehydratase HisB. | Putative threonine-phosphate decarboxylase CobD. | 0.927 |
hisB | hisA | TKV_c18450 | TKV_c18430 | Imidazoleglycerol-phosphate dehydratase HisB. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. | 0.997 |
hisB | hisC | TKV_c18450 | TKV_c18460 | Imidazoleglycerol-phosphate dehydratase HisB. | Histidinol-phosphate aminotransferase HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |