node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIT65806.1 | SIT65836.1 | SAMN05216526_0259 | SAMN05216526_0291 | Homoserine dehydrogenase. | Aspartate kinase; Belongs to the aspartokinase family. | 0.979 |
SIT65806.1 | SIT65890.1 | SAMN05216526_0259 | SAMN05216526_0346 | Homoserine dehydrogenase. | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.694 |
SIT65806.1 | SIT70012.1 | SAMN05216526_0259 | SAMN05216526_1212 | Homoserine dehydrogenase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.748 |
SIT65806.1 | SIT70642.1 | SAMN05216526_0259 | SAMN05216526_1364 | Homoserine dehydrogenase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.970 |
SIT65806.1 | ahcY | SAMN05216526_0259 | SAMN05216526_1211 | Homoserine dehydrogenase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.862 |
SIT65806.1 | ilvA | SAMN05216526_0259 | SAMN05216526_0631 | Homoserine dehydrogenase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.723 |
SIT65806.1 | metZ | SAMN05216526_0259 | SAMN05216526_1664 | Homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.933 |
SIT65836.1 | SIT65806.1 | SAMN05216526_0291 | SAMN05216526_0259 | Aspartate kinase; Belongs to the aspartokinase family. | Homoserine dehydrogenase. | 0.979 |
SIT65836.1 | SIT65890.1 | SAMN05216526_0291 | SAMN05216526_0346 | Aspartate kinase; Belongs to the aspartokinase family. | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.563 |
SIT65836.1 | SIT70012.1 | SAMN05216526_0291 | SAMN05216526_1212 | Aspartate kinase; Belongs to the aspartokinase family. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.709 |
SIT65836.1 | SIT70642.1 | SAMN05216526_0291 | SAMN05216526_1364 | Aspartate kinase; Belongs to the aspartokinase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.962 |
SIT65836.1 | ahcY | SAMN05216526_0291 | SAMN05216526_1211 | Aspartate kinase; Belongs to the aspartokinase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.500 |
SIT65836.1 | ilvA | SAMN05216526_0291 | SAMN05216526_0631 | Aspartate kinase; Belongs to the aspartokinase family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.680 |
SIT65836.1 | metK | SAMN05216526_0291 | SAMN05216526_0309 | Aspartate kinase; Belongs to the aspartokinase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.452 |
SIT65836.1 | metZ | SAMN05216526_0291 | SAMN05216526_1664 | Aspartate kinase; Belongs to the aspartokinase family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.713 |
SIT65890.1 | SIT65806.1 | SAMN05216526_0346 | SAMN05216526_0259 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Homoserine dehydrogenase. | 0.694 |
SIT65890.1 | SIT65836.1 | SAMN05216526_0346 | SAMN05216526_0291 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aspartate kinase; Belongs to the aspartokinase family. | 0.563 |
SIT65890.1 | SIT70012.1 | SAMN05216526_0346 | SAMN05216526_1212 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.623 |
SIT65890.1 | SIT70642.1 | SAMN05216526_0346 | SAMN05216526_1364 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.955 |
SIT65890.1 | ahcY | SAMN05216526_0346 | SAMN05216526_1211 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.831 |