Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
icc3-prime,5-prime cyclic nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)    
Predicted Functional Partners:
mazG
MazG protein.
  
  
  0.916
purB
Adenylosuccinate lyase; Adenylosuccinase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
     
 0.906
surE
Acid phosphatase stationary-phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
  0.900
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
  0.900
cyaA
Adenylate cyclase.
  
   
 0.710
crp
Cyclic AMP receptor protein.
  
   
 0.592
glnA
Glutamine synthetase; Glutamate--ammonia ligase.
       0.434
HD_0748
Conserved hypothetical protein; Belongs to the P-Pant transferase superfamily.
       0.432
HD_1284
Conserved hypothetical protein; Belongs to the UPF0260 family.
  
     0.415
Your Current Organism:
Haemophilus ducreyi
NCBI taxonomy Id: 233412
Other names: Haemophilus ducreyi 35000HP, Haemophilus ducreyi str. 35000HP, [. ducreyi 35000HP, [Haemophilus] ducreyi 35000HP
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