node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ftsH | hflC | HD_1500 | HD_1808 | Cell division protein, FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | HflC protein; HflC and HflK could regulate a protease. | 0.915 |
ftsH | hflK | HD_1500 | HD_1809 | Cell division protein, FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | HflK protein; HflC and HflK could encode or regulate a protease. | 0.926 |
ftsH | yidC | HD_1500 | HD_0040 | Cell division protein, FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.486 |
hflC | ftsH | HD_1808 | HD_1500 | HflC protein; HflC and HflK could regulate a protease. | Cell division protein, FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.915 |
hflC | hflK | HD_1808 | HD_1809 | HflC protein; HflC and HflK could regulate a protease. | HflK protein; HflC and HflK could encode or regulate a protease. | 0.992 |
hflC | hflX | HD_1808 | HD_0740 | HflC protein; HflC and HflK could regulate a protease. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.517 |
hflC | macB | HD_1808 | HD_1019 | HflC protein; HflC and HflK could regulate a protease. | Macrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.419 |
hflC | miaA | HD_1808 | HD_0742 | HflC protein; HflC and HflK could regulate a protease. | tRNA delta-2-isopentylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.407 |
hflC | purA | HD_1808 | HD_1807 | HflC protein; HflC and HflK could regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.529 |
hflC | trxA | HD_1808 | HD_1810 | HflC protein; HflC and HflK could regulate a protease. | Thioredoxin; Belongs to the thioredoxin family. | 0.445 |
hflC | yidC | HD_1808 | HD_0040 | HflC protein; HflC and HflK could regulate a protease. | 60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.441 |
hflK | ftsH | HD_1809 | HD_1500 | HflK protein; HflC and HflK could encode or regulate a protease. | Cell division protein, FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.926 |
hflK | hflC | HD_1809 | HD_1808 | HflK protein; HflC and HflK could encode or regulate a protease. | HflC protein; HflC and HflK could regulate a protease. | 0.992 |
hflK | hflX | HD_1809 | HD_0740 | HflK protein; HflC and HflK could encode or regulate a protease. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.730 |
hflK | macB | HD_1809 | HD_1019 | HflK protein; HflC and HflK could encode or regulate a protease. | Macrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.419 |
hflK | miaA | HD_1809 | HD_0742 | HflK protein; HflC and HflK could encode or regulate a protease. | tRNA delta-2-isopentylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.463 |
hflK | purA | HD_1809 | HD_1807 | HflK protein; HflC and HflK could encode or regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.550 |
hflK | trxA | HD_1809 | HD_1810 | HflK protein; HflC and HflK could encode or regulate a protease. | Thioredoxin; Belongs to the thioredoxin family. | 0.456 |
hflK | yidC | HD_1809 | HD_0040 | HflK protein; HflC and HflK could encode or regulate a protease. | 60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.546 |
hflX | hflC | HD_0740 | HD_1808 | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | HflC protein; HflC and HflK could regulate a protease. | 0.517 |